NEST360's low-cost jaundice detector passes first test in Africa

December 4, 2017, Rice University
BiliSpec is a low-cost, battery-powered reader designed to diagnose jaundice by immediately quantifying serum bilirubin levels from a small drop of whole blood. Credit: Jeff Fitlow/Rice University

The first clinical study of a low-cost, hand-held jaundice detector invented by Rice University students couldn't have come at a better time for NEST360°, an international team of scientists, doctors and global health experts preparing for a Dec. 11 competition for $100 million from the MacArthur Foundation. The money would allow the team to carry out its visionary plan to halve the number of newborn deaths in African hospitals within 10 years.

"As the clinical study of BiliSpec shows, saving newborn lives in sub-Saharan Africa is achievable," said NEST360°'s Rebecca Richards-Kortum, a Rice bioengineering professor and study co-author who has worked for more than a decade to bring effective, affordable neonatal technologies like BiliSpec to Africa. "It simply requires the right tools in the right hands at the right time."

The clinical study, which is based on tests in February and March on 68 patients at Queen Elizabeth Central Hospital in Blantyre, Malawi, will appear this week in the Early Edition of the Proceedings of the National Academy of Sciences.

BiliSpec is a low-cost, battery-powered reader designed to diagnose by immediately quantifying serum bilirubin levels from a small drop of whole blood. Jaundice, which is caused by the buildup of bilirubin in the bloodstream, affects about 60 percent of newborns and can cause severe, untreatable brain damage or death if it is untreated. Standard jaundice tests require multiple expensive disposables and laboratory equipment like centrifuges or spectrophotometers that African hospitals typically cannot afford.

Rice University students (from left) Mathieu Simeral, Pelham Keahey and Kristofer Schroder helped complete the first clinical study of BiliSpec, a low-cost, battery-powered reader designed to diagnose jaundice by immediately quantifying serum bilirubin levels from a small drop of whole blood. BiliSpec is one component of a 17-piece neonatal package called NEST, short for Newborn Essential Solutions and Technologies, that is designed specifically for African hospitals by NEST360°, an international team of scientists, doctors and global health experts. Credit: Jeff Fitlow/Rice University

Babies in sub-Saharan Africa are about 100 times more likely to die of jaundice than are babies in the U.S., partly because doctors diagnosing jaundice in sub-Saharan Africa have little to go on other than what their eyes tell them.

"Clinicians in sub-Saharan Africa typically diagnose jaundice by looking at a child and gauging the color of their skin or the whites of their eyes," said study co-author Pelham Keahey, a Rice applied physics graduate student who worked alongside clinicians at Queen Elizabeth Central Hospital to gather data for the study.

The study showed that BiliSpec has comparable accuracy to the more expensive laboratory tests found in high-resource settings. Each BiliSpec test costs about 5 cents and can be performed in about two minutes right at the patient's bedside. The price is important because it could bring testing for jaundice within reach for cash-strapped hospitals in sub-Saharan Africa.

"The next step is a larger, two-year follow-up study of efficacy and usability that will be conducted at five hospitals in Malawi," Keahey said. Rice won funding for the follow-up study in August from Saving Lives at Birth, a joint undertaking by the U.S. Agency for International Development (USAID), the Bill & Melinda Gates Foundation and the governments of Norway, Canada and South Korea.

BiliSpec is one component of a 17-piece neonatal package called NEST, short for Newborn Essential Solutions and Technologies, that is designed specifically for African hospitals.

Explore further: Severe newborn jaundice could be preventable, mouse study shows

More information: Pelham A. Keahey el al., "Point-of-care device to diagnose and monitor neonatal jaundice in low-resource settings," PNAS (2017). www.pnas.org/cgi/doi/10.1073/pnas.1714020114

Related Stories

Prize will expand use of life-saving neonatal device in Africa

November 14, 2013

A low-cost device that Rice University bioengineering students invented to help premature babies breathe more easily will be rolled out to teaching hospitals in three African nations, thanks to a $400,000 award from pharmaceutical ...

Illuminated pajamas treat newborns

October 31, 2017

Alone, naked, and with their eyes covered for protection: this is how newborns lie in incubators when they are being treated for jaundice. Irradiation with blue light in an incubator is necessary because toxic decomposition ...

Recommended for you

Under-fire Apple removes 25,000 apps in China

August 20, 2018

Apple said Monday it had removed many gambling-related apps from its Chinese app store as the US giant comes under scrutiny amid trade tensions between Beijing and Washington.

Robots as tools and partners in rehabilitation

August 17, 2018

In future decades, the need for effective strategies for medical rehabilitation will increase significantly, because patients' rate of survival after diseases with severe functional deficits, such as a stroke, will increase. ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.