Microscopic membrane could fight gum disease

Microscopic membrane could fight gum disease
Images of the team's membrane (left) and the zinc nanoparticles (right) embedded within it. Credit: Advanced Functional Materials / Wiley-VCH

Periodontitis – an advanced form of gum disease that breaks down tissue and bones housing the teeth – affects more than 70 percent of adults aged 65 and older. Engineers have devised various ways to combat the issue, one of which involves covering the gums with microscopic membranes that can halt the advance of bacteria and promote the regrowth of healthy tissue or bone.

Husker engineer Ali Tamayol, alongside colleagues from UCLA and Harvard Medical School, have now developed a flexible, biodegradable membrane made from a polymer containing nanoparticles of zinc oxide.

So what?

Existing biodegradable designs often struggle with some combination of several challenges: strong but time-controlled adhesion to the gums, bacteria-fighting capability and the reliable regeneration of essential cells.

Tamayol and his colleagues showed that they could control the degradation rate of their membrane by adjusting the properties of its polymer. As expected, the membrane's zinc oxide nanoparticles succeeded in killing periodontitis-causing bacteria. And the team found that its membrane spurred substantial bone growth when attached to the gums of rats suffering from periodontitis.

Now what?

The researchers are calibrating the concentration of zinc nanoparticles to determine which level best balances the 's bacteria-fighting and cell-regenerating properties.


Explore further

Are you ignoring gum disease?

More information: Amir Nasajpour et al. A Multifunctional Polymeric Periodontal Membrane with Osteogenic and Antibacterial Characteristics, Advanced Functional Materials (2017). DOI: 10.1002/adfm.201703437
Journal information: Advanced Functional Materials

Citation: Microscopic membrane could fight gum disease (2017, November 13) retrieved 20 July 2019 from https://phys.org/news/2017-11-microscopic-membrane-gum-disease.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
32 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more