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Microbes could make drug production more efficient

Alkaloid-based pharmaceuticals derived from plants can be potent treatments for a variety of illnesses. But getting these powerful therapeutic agents from plants can take a long time and cost plenty of money, because it often ...

date23 hours ago in Biochemistry
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Structural knowledge of the DNA repair complex

New Danish research provides mechanistic insight into how DNA is monitored and repaired if damage occurs. The results may eventually help to improve the treatment of certain types of cancer, as the DNA repair complex provides ...

dateMar 21, 2017 in Biochemistry
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How protein modifications influence apoptosis

Researchers at the Lomonosov Moscow State University have described the molecular mechanisms of post-translational modifications of caspases, a family of proteolytic enzymes, and how they function during apoptosis, the process ...

dateMar 21, 2017 in Biochemistry
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Altering pH bumps prions out of danger zone

Prion diseases are scary, incurable and fatal. They first gained notoriety when cows became infected by prion proteins and, in turn, infected people. Fervor surrounding mad cow disease resulted in the U.S. banning imports ...

dateMar 20, 2017 in Biochemistry
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A multidrug efflux pump in motion

Researchers at Vanderbilt University Medical Center have mapped the conformational changes that occur in a protein "notorious" for pumping chemotherapeutic drugs out of cancer cells and blocking medications from reaching ...

dateMar 13, 2017 in Biochemistry
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A kiss of death to drug the 'undruggable'

Scientists at the University of Dundee have reported a major breakthrough in targeting the causes of many diseases, using a `kiss of death' to destroy proteins which had previously been regarded as 'undruggable'.

dateMar 13, 2017 in Biochemistry
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Small molecules fighting aging-related diseases

For the first time an international research network led by Bayreuth Biochemist Prof. Dr. Clemens Steegborn has succeeded in producing small molecules able to activate the enzyme sirtuin 6. Furthermore, the scientists were ...

dateMar 08, 2017 in Biochemistry
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A bright 'glow stick' marker for cells

Any child who has played with a glowstick or captured a firefly understands the wonder of chemiluminescence, or chemical light. This process is already used to detect blood at crime scenes and to determine the concentrations ...

A step toward red-light regulated optogenetic tools

The aim of optogenetics is to control genetically modified cells using light. A team of Graz scientists led by Andreas Winkler from the Institute of Biochemistry at TU Graz have set a milestone in the future development of ...

Frozen chemistry controls bacterial infections

Chemists and molecular biologists have made an unexpected discovery in infection biology. The researchers can now show that two proteins that bind to one another slow down a chemical reaction central to the course of the ...

Team discovers many new twists in protein folding

Biophysicists at JILA have measured protein folding in more detail than ever before, revealing behavior that is surprisingly more complex than previously known. The results suggest that, until now, much about protein behavior ...

Supramolecular protein fishing with molecular baits

Scientists from the Center for Self-assembly and Complexity (CSC) successfully isolated a cancer-prone protein by fishing out the proteins using 'molecular bait'. Cancer, according to the American Cancer Society, affects ...

Researchers imitate molecular crowding in cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for ...

Rare proteins collapse earlier

Some organisms are able to survive in hot springs, while others can only live at mild temperatures because their proteins aren't able to withstand such extreme heat. ETH researchers investigated these differences and showed ...

Cell 'stickiness' could indicate metastatic potential

How strongly tumor cells adhere to the surrounding tissue could indicate the likelihood that cancer will spread to other parts of the body, according to a study published February 28 in Biophysical Journal. Using a spinning ...

New technology offers fast peptide synthesis

Manufacturing small proteins known as peptides is usually very time-consuming, which has slowed development of new peptide drugs for diseases such as cancer, diabetes, and bacterial infections.

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Mathematical framework explains diverse plant stem forms
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Argon is not the 'dope' for metallic hydrogen
How chewing like a cow helped early mammals thrive
New tools to study the origin of embryonic stem cells

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