CRISPR insight: How to fine-tune Cas protein's grip on DNA

At the heart of every CRISPR reaction, whether naturally occurring in bacteria or harnessed by CRIPSR-Cas gene editing technology, is a strong molecular bond of a Cas protein via a guide RNA to its target site on DNA. It's ...

Researchers develop new tool for targeted cell control

Thanks to new RNA vaccines, we humans have been able to protect ourselves incredibly quickly from new viruses like SARS-CoV-2, the virus that causes COVID-19. These vaccines insert a piece of ephemeral genetic material into ...

Physical mechanisms explaining DNA and RNA twist changes

The double-helix structure of DNA is deformed by environmental stimuli, which will then affect gene expression, and eventually trigger a sequence of cellular processes. Recent research led by a physicist from City University ...

The first stages of DNA evolution

One fundamental question in the field of the Origin of Life is how the first molecules of DNA replicated and evolved on the primordial Earth, more than 4 billion years ago. Before the emergence of the first cells or any other ...

Study rewrites dogma of adenovirus infection and double-stranded RNA

Challenging the dogma of what scientists thought they understood about DNA viruses, a team of researchers led by Children's Hospital of Philadelphia (CHOP) has shown that adenovirus uses its own efficient RNA splicing mechanisms ...

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