While we often think of diseases as caused by foreign bodies—bacteria or viruses—there are hundreds of diseases affecting humans that result from errors in cellular production of proteins.
Cell & Microbiology
Dec 4, 2023
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323
Scientists at the University of Bath have used nature as inspiration in developing a new tool that will help researchers develop new pharmaceutical treatments in a cleaner, greener, and less expensive way.
Biochemistry
Nov 28, 2023
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42
Methamphetamine (meth) abuse is a major health concern. Understanding how meth interacts with its target proteins is crucial for the development of novel medications to address drug addiction. Previous research into the mechanism ...
Biochemistry
Nov 24, 2023
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53
Investigators led by Neil Kelleher, Ph.D., professor of Medicine in the Division of Hematology and Oncology and of Biochemistry and Molecular Genetics, have developed an automated technique for imaging and identifying proteoforms ...
Biotechnology
Nov 10, 2023
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48
A new study from the University of Eastern Finland shows that the delivery of drugs into the brain, and especially into glial cells, can be enhanced with prodrugs that temporarily incorporate thyroxine or a thyroxine-like ...
Biochemistry
Nov 8, 2023
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45
Biological markers, commonly referred to markers or biomarkers, serve as quantifiable and measurable indicators of certain biological states in normal and pathogenic processes, as well as potential pharmacologic responses ...
Plants & Animals
Nov 2, 2023
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23
Accurately predicting the drug-protein interaction (DPI) is crucial in virtual drug screening. However, current methodologies tend to allocate equal weighting to amino acids and atoms in encoding protein and drug sequences, ...
Biochemistry
Nov 1, 2023
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1
A detailed atomic exploration into how the dengue virus replicates its genome could catalyze the development of high-precision targeted antiviral therapeutics.
Cell & Microbiology
Oct 31, 2023
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1
Researchers at the Icahn School of Medicine at Mount Sinai have identified the structure of a special transporter found in red blood cells and how it interacts with drugs. Details on the findings, which were reported in the ...
Molecular & Computational biology
Sep 7, 2023
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81
Membrane proteins play a pivotal role in various cellular functions and are key targets for pharmaceutical interventions. In fact, approximately 60% of drugs currently available on the market target these specific proteins. ...
Molecular & Computational biology
Sep 7, 2023
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1
