New atom-level insight into drug-target residence time
A new study from the University of Eastern Finland and the University of TĂĽbingen helps to explain what defines how long a drug molecule stays bound to its target.
A new study from the University of Eastern Finland and the University of TĂĽbingen helps to explain what defines how long a drug molecule stays bound to its target.
Molecular & Computational biology
Jan 28, 2022
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11
Toxoplasma gondii, the parasite responsible for toxoplasmosis, is capable of infecting almost all cell types. It is estimated that up to 30% of the world's population is chronically infected, the vast majority asymptomatically. ...
Cell & Microbiology
Jun 24, 2021
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9
Almost all cells in our body contain a nucleus: a somewhat spherical structure that is separated from the rest of the cell by a membrane. Each nucleus contains all the genetic information of the human being. It serves as ...
Molecular & Computational biology
Jun 22, 2021
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6
A study performed by researchers at the Institute for Advanced Chemistry of Catalonia (IQAC-CSIC) from the Spanish National Research Council (CSIC) in collaboration with Stony Brook University (U.S.) proposes a new strategy ...
Biochemistry
Jun 17, 2021
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8
The biological clock is present in almost all cells of an organism. As more and more evidence emerges that clocks in certain organs could be out of sync, there is a need to investigate and reset these clocks locally. Scientists ...
Molecular & Computational biology
May 26, 2021
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2489
Researchers from the Carl R. Woese Institute for Genomic Biology in collaboration with scientists at Oxford University have published a paper in Cell reporting the function of LanCL proteins. These proteins are found in eukaryotic ...
Cell & Microbiology
Apr 30, 2021
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67
The human cellular kinome contains over 500 kinases, accounting for almost 2% of all our genes. It is currently impossible to gauge the phosphorylation status, or even phosphorylation potential, of the entire proteome of ...
Research led by The Ohio State University Wexner Medical Center and College of Medicine identified a new compound that might serve as a basis for developing a new class of drugs for diabetes.
Biochemistry
Jan 26, 2021
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26
In order for tumors to successfully take hold and spread in the body, they typically must meet several developmental milestones. These include things like suppressing apoptosis, cultivating replication and angiogenesis, weaning ...
Two studies led by UT Southwestern researchers shed light on the biology and potential vulnerabilities of schistosomes—parasitic flatworms that cause the little-known tropical disease schistosomiasis. The findings, published ...
Cell & Microbiology
Sep 24, 2020
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147