Researchers at Children's Hospital of Philadelphia (CHOP) have identified genes responsible for hematopoietic stem cell (HSC) regeneration via the assembly of the ribosome, the protein factories in cells that translate mRNA ...
Cell & Microbiology
Mar 11, 2021
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A protein that masterminds the way DNA is wrapped within chromosomes has a major role in the healthy functioning of blood stem cells, which produce all blood cells in the body, according to a new study from researchers at ...
Cell & Microbiology
Jan 31, 2022
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From the moment of fertilization, building a human body involves a series of choices where cells generated by cell division must elect which of the myriad types of cell they will become. How does this decision occur? New ...
Cell & Microbiology
Jul 27, 2017
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Blood cells make up the majority of cells in the human body. They perform critical functions and their dysfunction is implicated in many important human diseases, from anemias to blood cancers like leukemia. The many types ...
Cell & Microbiology
Jan 31, 2024
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53
Throughout one's life, the blood is constantly being replenished from blood stem cells. However, these cells lose their functionality in old age. Researchers at the Leibniz Institute on Aging—Fritz Lipmann Institute (FLI) ...
Cell & Microbiology
Jun 17, 2022
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Hematopoietic stem cells (HSCs) give rise to all blood and immune cells throughout the life of vertebrate organisms, from zebrafish to humans. But details of their genesis remain elusive, hindering efforts to develop induced ...
Cell & Microbiology
Nov 6, 2014
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Blood plays the important role of transporting oxygen and hormones necessary for the human body. Blood contains blood cells, such as erythrocytes, neutrophils, and lymphocytes, which are generated from hematopoietic stem ...
Cell & Microbiology
Jul 4, 2018
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Hematopoietic stem/progenitor cells (HSPCs) include hematopoietic stem cells and several lineage-biased hematopoietic progenitor cells, which can provide all blood cell types in an adult organism. Among them, hematopoietic ...
Cell & Microbiology
Mar 26, 2021
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Blood cells originate from a small pool of hematopoietic stem cells (HSCs) through a complex process of differentiation steps that are tightly regulated at the transcriptional level. Dissecting the mechanisms underlying this ...
Cell & Microbiology
Oct 5, 2012
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A study from Patrick Matthias and his group at the FMI challenges a widely accepted model on how epigenome dynamics control the differentiation of hematopoietic cells. The plasticity of pluripotent stem cells was thought ...
Cell & Microbiology
Oct 20, 2015
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