Astronauts are at higher risk for developing mutations—possibly linked to spaceflight—that can increase the risk of developing cancer and heart disease during their lifetimes, according to a first-of-its kind study from ...
Space Exploration
Aug 31, 2022
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371
The origins of our blood may not be quite what we thought. Using cellular "barcoding" in mice, a groundbreaking study finds that blood cells originate not from one type of mother cell, but two, with potential implications ...
Cell & Microbiology
Jun 15, 2022
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136
Researchers have transplanted genetically modified hematopoietic stem cells into mice so that their developing red blood cells produce a critical lysosomal enzyme -preventing or reducing organ and central nervous system damage ...
Cell & Microbiology
Nov 9, 2009
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0
In humanity's ongoing quest for the elixir of life, the science keeps pointing to stem cells. Research increasingly shows that maintaining stem cell fitness promotes a long healthspan, and new findings show keeping stem cells ...
Cell & Microbiology
Mar 21, 2023
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78
Hematopoietic stem cells (HSCs) are important immature blood cells in bone marrow that can be triggered to develop into any blood cell type. HSC transplants can be used to treat conditions where bone marrow is damaged and ...
Cell & Microbiology
Feb 27, 2023
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48
The body is constantly replenishing the blood with new red and white blood cells thanks to a small but important group of cells called hematopoietic stem cells (HSCs). Now, researchers at the Broad Institute of MIT Harvard, ...
Cell & Microbiology
Feb 17, 2023
0
20
Endothelial cells (ECs) line blood vessels and can serve as specialized vascular niches for hematopoietic stem and progenitor cells (HSPCs), a special environment where HSPCs reside and self-renew. A team of researchers found ...
Cell & Microbiology
Jan 24, 2023
0
70
A new statistical method provides a more efficient way to uncover biologically meaningful changes in genomic data that span multiple conditions—such as cell types or tissues.
Molecular & Computational biology
Nov 14, 2022
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56
A well-functioning immune system is essential for protection against infections. However, with increasing age, the functioning of the immune system diminishes, which is also due to age-related damage in hematopoietic (blood) ...
Cell & Microbiology
Oct 10, 2022
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116
The fetal liver is the major hematopoietic organ during the embryonic stage. It is generally believed that hematopoietic hierarchy in the fetal liver is established through the differentiation of fetal hematopoietic stem ...
Cell & Microbiology
Sep 21, 2022
0
58
Hematopoietic stem cells (HSCs) are multipotent stem cells that give rise to all the blood cell types including myeloid (monocytes and macrophages, neutrophils, basophils, eosinophils, erythrocytes, megakaryocytes/platelets, dendritic cells), and lymphoid lineages (T-cells, B-cells, NK-cells). The definition of hematopoietic stem cells has undergone considerable revision in the last two decades. The hematopoietic tissue contains cells with long-term and short-term regeneration capacities and committed multipotent, oligopotent, and unipotent progenitors. Recently, long-term transplantation experiments point toward a clonal diversity model of hematopoietic stem cells. Here, the HSC compartment consists of a fixed number of different types of HSC, each with epigenetically preprogrammed behavior. This contradicts older models of HSC behavior, which postulated a single type of HSC that can be continuously molded into different subtypes of HSCs. HSCs constitute 1:10.000 of cells in myeloid tissue.
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