The molecular tool CRISPR-Cas9 can be used to treat inherited blood disorders, but this may cause unintended genetic alterations. A team led by MDC researchers Klaus Rajewsky and Van Trung Chu has now presented an approach ...
Biotechnology
Jun 23, 2022
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37
Not all adult stem cells are created equal. Some are busy regenerating worn out or damaged tissues, while their quieter brethren serve as a strategic back-up crew that only steps in when demand shoots up. Now, researchers ...
Cell & Microbiology
Jul 19, 2012
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0
Hematopoietic stem cells, that form mature blood cells, require a very precise amount of protein to function – and defective regulation of protein production is common in certain types of aggressive human blood cancers. ...
Cell & Microbiology
Apr 6, 2018
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4
Hematopoietic stem cells provide the body with a constant supply of blood cells, including the red blood cells that deliver oxygen and the white blood cells that make up the immune system. Hematopoietic -- or blood -- stem ...
Cell & Microbiology
Aug 4, 2010
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0
The fetal liver is the major hematopoietic organ during the embryonic stage. It is generally believed that hematopoietic hierarchy in the fetal liver is established through the differentiation of fetal hematopoietic stem ...
Cell & Microbiology
Sep 21, 2022
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58
Dormancy is a sleep-like state of cells that protects them from genetic damage and thus prolongs their survival. This state is reversible and characterized by low metabolic activity and division rate. Researchers from the ...
Biotechnology
Jun 23, 2021
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7
A readily available, inexpensive, small molecule drug can improve the fitness of hematopoietic stem and progenitor cells (HSPCs) that are modified outside the body, potentially improving the success of procedures such as ...
Cell & Microbiology
Sep 27, 2023
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1
Hematopoietic stem and progenitor cells (HSPCs) give rise to all blood lineages that support life. HSPCs, like seeds, need a suitable microenvironment to maintain their function. A process called "homing" allows HSPCs to ...
Cell & Microbiology
Nov 21, 2018
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3
A new statistical method provides a more efficient way to uncover biologically meaningful changes in genomic data that span multiple conditions—such as cell types or tissues.
Molecular & Computational biology
Nov 14, 2022
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56
hematopoietic stem cells (HSCs) are responsible for the constant replenishment of all blood cells throughout life. One of the major challenges in regenerative medicine is to produce tailor-made HSCs to replace the defective ...
Cell & Microbiology
Nov 4, 2019
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46
