Related topics: stem cells · blood cells · leukemia · bone marrow

New method to boost supply of life-saving stem cells

Researchers at the Center for Genomic Regulation (CRG) in Barcelona and Columbia University in New York City have identified a protein that is critical for the expansion of typically scarce, life-saving blood stem cells.

Adipose tissue produces cells involved in immune response

French researchers from CNRS and the Universite Paul Sabatier have demonstrated the existence, in adipose tissue, of stem cells similar to those found in bone marrow. These cells are capable of differentiating into mast cells, ...

Scientists successfully reprogram blood cells

Researchers have transplanted genetically modified hematopoietic stem cells into mice so that their developing red blood cells produce a critical lysosomal enzyme -preventing or reducing organ and central nervous system damage ...

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Hematopoietic stem cell

Hematopoietic stem cells (HSCs) are multipotent stem cells that give rise to all the blood cell types including myeloid (monocytes and macrophages, neutrophils, basophils, eosinophils, erythrocytes, megakaryocytes/platelets, dendritic cells), and lymphoid lineages (T-cells, B-cells, NK-cells). The definition of hematopoietic stem cells has undergone considerable revision in the last two decades. The hematopoietic tissue contains cells with long-term and short-term regeneration capacities and committed multipotent, oligopotent, and unipotent progenitors. Recently, long-term transplantation experiments point toward a clonal diversity model of hematopoietic stem cells. Here, the HSC compartment consists of a fixed number of different types of HSC, each with epigenetically preprogrammed behavior. This contradicts older models of HSC behavior, which postulated a single type of HSC that can be continuously molded into different subtypes of HSCs. HSCs constitute 1:10.000 of cells in myeloid tissue.

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