A next-generation gene-editing system developed by Carnegie Mellon University and Yale University scientists has successfully cured a genetic blood disorder in living mice using a simple IV treatment. Unlike the popular CRISPR ...
Biotechnology
Oct 26, 2016
0
1648
Astronauts are at higher risk for developing mutations—possibly linked to spaceflight—that can increase the risk of developing cancer and heart disease during their lifetimes, according to a first-of-its kind study from ...
Space Exploration
Aug 31, 2022
0
371
Researchers at the Center for Genomic Regulation (CRG) in Barcelona and Columbia University in New York City have identified a protein that is critical for the expansion of typically scarce, life-saving blood stem cells.
Cell & Microbiology
Dec 8, 2020
0
332
Biologists at UC San Diego have identified the specific region in vertebrates where adult blood stem cells arise during embryonic development.
Cell & Microbiology
Feb 14, 2010
1
0
In your home, storing books on a bookshelf, tools in a tool box, and a broom in a broom cupboard makes it easy to access these items whenever you need them. Within the body, hematopoietic stem cells (HSCs) reside in their ...
Cell & Microbiology
Jun 9, 2022
0
35
When infections occur in the body, stem cells in the blood often jump into action by multiplying and differentiating into mature immune cells that can fight off illness. But repeated infections and inflammation can deplete ...
Cell & Microbiology
May 21, 2013
0
0
Simple physics may play a larger role than previously thought in helping control key bodily processes such as how the body fights infection.
General Physics
Feb 8, 2016
2
32
The origins of our blood may not be quite what we thought. Using cellular "barcoding" in mice, a groundbreaking study finds that blood cells originate not from one type of mother cell, but two, with potential implications ...
Cell & Microbiology
Jun 15, 2022
0
136
Scientists have combined laser 3D printing technology and an alternate soaking process to construct complex 3D structures that mimic bone microstructure. This is the first demonstration of this fabrication method, and it ...
Biochemistry
Feb 12, 2024
0
64
French researchers from CNRS and the Universite Paul Sabatier have demonstrated the existence, in adipose tissue, of stem cells similar to those found in bone marrow. These cells are capable of differentiating into mast cells, ...
Cell & Microbiology
Nov 26, 2010
0
0
Hematopoietic stem cells (HSCs) are multipotent stem cells that give rise to all the blood cell types including myeloid (monocytes and macrophages, neutrophils, basophils, eosinophils, erythrocytes, megakaryocytes/platelets, dendritic cells), and lymphoid lineages (T-cells, B-cells, NK-cells). The definition of hematopoietic stem cells has undergone considerable revision in the last two decades. The hematopoietic tissue contains cells with long-term and short-term regeneration capacities and committed multipotent, oligopotent, and unipotent progenitors. Recently, long-term transplantation experiments point toward a clonal diversity model of hematopoietic stem cells. Here, the HSC compartment consists of a fixed number of different types of HSC, each with epigenetically preprogrammed behavior. This contradicts older models of HSC behavior, which postulated a single type of HSC that can be continuously molded into different subtypes of HSCs. HSCs constitute 1:10.000 of cells in myeloid tissue.
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