Structural insight into process of gene regulation

In the cell nucleus, numerous proteins bind to the DNA molecule in order to regulate the activity of certain genes. One of these is the TATA-box binding protein (TBP), which binds to a specific DNA sequence and constitutes ...

Study finds new pathway for clearing misfolded proteins

Misfolded proteins are toxic to cells. They disrupt normal functions and cause some age-related human degenerative diseases, like Alzheimer's, Parkinson's, and Huntington's diseases. Cells work constantly to eliminate misfolded ...

DNA packaging supports cell division, finds study

The DNA molecule is located in the cell nucleus as a densely packed complex of DNA and protein, known as chromatin. Wrapped in sections around a core of special proteins known as histones, the DNA forms so-called nucleosomes, ...

Long-standing mystery about mRNAs resolved

Messenger RNAs (mRNAs) contain chemical marks that are critical for antiviral defense in cells, according to a new study from researchers at Weill Cornell Medicine. The finding solves a 50-year mystery concerning the purpose ...

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