Dysregulated R-loops can cause stalled replication forks and telomere instability. However, how R-loops are recognized and regulated, is still not well understood, particularly at telomeres.
RNA—in the form of messenger RNA (mRNA), ribosomal RNA (rRNA), and transfer RNA (tRNA)—transforms the genome coded by DNA into proteins that form the backbone of all cellular functions. However, biochemical modifications ...
Helicases are enzymes that unwind DNA and RNA. They're central to cellular life, implicated in a number of cancers and infections—and, alas, extraordinarily difficult to target with drugs.
Genetic expression, often leading to protein synthesis, requires a complex coordination of molecular machinery across several stages. A vital step in protein-coding gene expression is messenger RNA (mRNA) export, which involves ...
Two papers published in PNAS Nexus describe the genetic basis of long-term heat tolerance in the model plant Arabidopsis thaliana, with implications for crop breeding. Teruaki Taji and colleagues evaluated dozens of lines ...
Research led by Duke University, Durham, has discovered a situation-dependent traffic jam in mRNA translation caused by RNA hairpins leading to higher translation of upstream start codons (uAUGs).
Scientific research requires patience. The rewards are not always immediate, and the technology needed does not always exist. Michael A. Trakselis, Ph.D., professor and director of graduate affairs for the Department of Chemistry ...
New Cleveland Clinic research shows how mosquito-transmitted viruses—like Zika, West Nile, Yellow Fever and dengue viruses—hijack host cells to promote their own replication and infection. Published in Cell Host and Microbe, ...
You're likely familiar with RNA, the molecule that plays an important role in protein production and gene expression control. Perhaps you're less familiar, however, with PIWI-interacting RNA (piRNA), a special type of RNA ...
A study on almost four thousand people of African descent has identified a gene that acts as natural defense against HIV by limiting its replication in certain white blood cells. An international effort co-led by EPFL, Canada's ...
