On your last nerve: Researchers advance understanding of stem cells

Nov 17, 2009
This is a high-resolution image of the surface of the adult stem cell niche in a mouse brain with a genetic label that makes FoxJ1+ cells green. Subsets of red and blue cells constitute adult stem cells and are largely distinct from FoxJ1+ cells. Credit: North Carolina State University

Researchers from North Carolina State University have identified a gene that tells embryonic stem cells in the brain when to stop producing nerve cells called neurons. The research is a significant advance in understanding the development of the nervous system, which is essential to addressing conditions such as Parkinson's disease, Alzheimer's disease and other neurological disorders.

The bulk of neuron production in the takes place before birth, and comes to a halt by birth. But scientists have identified specific regions in the core of the brain that retain stem cells into adulthood and continue to produce new neurons.

NC State researchers, investigating the subventricular zone, one of the regions that retains stem cells, have identified a gene that acts as a switch - transforming some into adult cells that can no longer produce new neurons. The research was done using mice. These cells form a layer of cells that support adult stem cells. The gene, called FoxJ1, increases its activity near the time of birth, when neural development slows down. However, the FoxJ1 gene is not activated in most of the stem cells in the subventricular zone - where new neurons continue to be produced into adulthood.

"Research into why and how some stem cells in the subventricular zone continue to produce new neurons is important because a biological understanding of how these cells function can contribute to new treatments to replace damaged or diseased , hopefully in regions that cannot do this by themselves," says Dr. Troy Ghashghaei, an assistant professor of neurobiology at NC State and the senior author of the research. "This research helps us understand brain development itself, which is key to identifying novel approaches for treatment of many neurological disorders."

These are genetically labeled FoxJ1+ cells (green) in a culture dish. These cells differentiate into a unique subset of cells that is distinguishable from known cell types in the adult stem cell niche in the mouse brain (the blue and red cells). Credit: North Carolina State University

When the FoxJ1 gene is activated, it produces a protein that functions as a transcription factor. swim through the nucleus of a cell turning other genes on and off, turning the embryonic stem cell into an adult cell. Some of the adult cells will function as stem cells, creating new neurons, but most will not - instead serving to support the by forming a stem cell "niche." This niche has a complex cellular architecture that allows adult to remain active in the subventricular zone.

Ghashghaei's lab is now moving forward with new research to determine what activates the FoxJ1 gene and how the FoxJ1 protein regulates the expression of other genes. This understanding will reveal how the activation and inactivation of genes controlled by FoxJ1 orchestrates the development of the adult stem cell niche. Ghashghaei's laboratory is a recent recipient of funding from the National Institutes of Health to support this line of research.

Source: North Carolina State University (news : web)

Explore further: Scientists throw light on the mechanism of plants' ticking clock

add to favorites email to friend print save as pdf

Related Stories

When is a stem cell not really a stem cell?

Aug 26, 2007

Working with embryonic mouse brains, a team of Johns Hopkins scientists seems to have discovered an almost-too-easy way to distinguish between “true” neural stem cells and similar, but less potent versions. Their finding, ...

Stem cells are good for the brain

Jul 15, 2008

For some years, scientists have been speculating over why stem cells exist in the brain, as brain regeneration is limited. A German team of neuroscientists believe these stem cells help keep the brain healthy and active.

Recommended for you

Microscopic rowing—without a cox

27 minutes ago

Many different types of cell, including sperm, bacteria and algae, propel themselves using whip-like appendages known as flagella. These protrusions, about one-hundredth of a millimetre long, function like ...

Illuminating the dark side of the genome

6 hours ago

Almost 50 percent of our genome is made up of highly repetitive DNA, which makes it very difficult to be analysed. In fact, repeats are discarded in most genome-wide studies and thus, insights into this part ...

Fighting bacteria—with viruses

Jul 24, 2014

Research published today in PLOS Pathogens reveals how viruses called bacteriophages destroy the bacterium Clostridium difficile (C. diff), which is becoming a serious problem in hospitals and healthcare institutes, due to its re ...

Atomic structure of key muscle component revealed

Jul 24, 2014

Actin is the most abundant protein in the body, and when you look more closely at its fundamental role in life, it's easy to see why. It is the basis of most movement in the body, and all cells and components ...

User comments : 0