Researchers study Terahertz radiation's impact on cellular function and gene expression

Sep 13, 2011

Terahertz (THz) technologies show promise for myriad medical, military, security, and research applications ranging from the detection of cancer to airport security systems to shipment inspection to spectroscopy. Relatively little is known, however, about the effect of THz radiation on biological systems. So a team of researchers, led by Los Alamos National Laboratory, evaluated the cellular response of mouse stem cells exposed to THz radiation. They applied low-power radiation both from a pulsed broadband (centered at 10 THz) source and from a continuous wave (CW) laser (2.52 THz) source, and applied both modeling and empirical characterization and monitoring techniques to minimize the impact of radiation-induced increases in temperature.

The researchers determined that temperature increases were minimal, and that expression was unaffected, while the expression of certain other genes showed clear effects of the THz irradiation. As the researchers describe in the September issue of the Optical Society's (OSA) open-access journal Biomedical , mouse mesenchymal stem cells exposed to THz radiation exhibit specific changes in cellular function closely related to the gene expression. They believe further investigations involving a large number of genes and variation in THz radiation characteristics and exposure duration are needed to generalize their findings. They also say that more direct experimental investigations of THz radiation's ability to induce specific openings of the DNA double strand are needed to fully determine how THz radiation may work through DNA dynamics to influence cellular function.

The team, led by Los Alamos National Lab, worked in collaboration with the Center for Integrated Nanotechnologies, a U.S. Department of Energy, Office of Basic Energy Sciences user facility at Los Alamos and Sandia National Laboratories, and with Harvard Medical School, and Beth Israel Deaconess Medical Center.

Explore further: New tool has potential for brain mapping

More information: "Non-thermal effects of terahertz radiation on gene expression in mouse stem cells," Biomedical Optics Express, Alexandrov et al., Volume 2, Issue 9, pp. 2679-2689. www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-9-2679

add to favorites email to friend print save as pdf

Related Stories

Terahertz-controlling device is built

Dec 04, 2006

U.S. government scientists say they've built a device that can manipulate terahertz radiation, perhaps leading to new imaging and communications devices.

Checking people at airports -- with terahertz radiation

Sep 18, 2008

Within the last few years the number of transport checks – above all at airports – has been increased considerably. A worthwhile effort as, after all, it concerns the protection of passengers. Possibilities for new and ...

Terahertz imaging goes the distance

Apr 26, 2007

Terahertz (THz) radiation, or far-infrared light, is potentially very useful for security applications, as it can penetrate clothing and other materials to provide images of concealed weapons, drugs, or other objects. However, ...

Torch-sized devices will detect disease and weapons

Oct 10, 2005

Researchers at the University of Essex have been awarded almost £1.2 million as part of a programme to develop a new generation of portable, handheld radiation detectors that could have a range of potential applications ...

Keeping an eye on the surroundings

Aug 13, 2008

Water is no passive spectator of biological processes; it is an active participant. Protein folding is thus a self-organized process in which the actions of the solvent play a key role. So far, the emphasis ...

Recommended for you

New tool has potential for brain mapping

May 16, 2013

A new tool being developed by UT Arlington assistant professor of physics could help scientists map and track the interactions between neurons inside different areas of the brain.

Quantum dot LED approaches theoretical maximum efficiency

May 14, 2013

(Phys.org) —Quantum dot LEDs (QLEDs) are a promising technology for creating large-area displays that could have applications for TVs, cell phones, and digital cameras. So far, however, the highest efficiencies ...

Photonic quantum computers: A brighter future than ever

May 13, 2013

(Phys.org) —Harnessing the unique features of the quantum world promises a dramatic speed-up in information processing as compared to the fastest classical machines. Scientists from the Group of Philip ...

User comments : 0

More news stories

Promising doped zirconia

Materials belonging to the family of dilute magnetic oxides (DMOs)—an oxide-based variant of the dilute magnetic semiconductors—are good candidates for spintronics applications. This is the object of ...

Bringing life into focus

Spinning-disk confocal microscopy is an optical imaging technique that can be used to generate detailed three-dimensional fluorescence images of living cells and their contents. Although a powerful tool for ...

Nanocrystals grow from liquid interface

An international collaboration of scientists has discovered a unique crystalizing behavior at the interface between two immiscible liquids that could aid in sustainable energy development.

US seizes Bitcoin operator accounts

US authorities seized the accounts of a Bitcoin digital currency exchange operator, claiming it was functioning as an "unlicensed money service business," court documents showed Friday.

Chinese, Indian airlines face EU pollution fines

Eight Chinese and two Indian airlines face fines of up to several million euros for not paying for their greenhouse gas emissions during flights within the bloc, the European Commission said on Friday.