Poultry research leads to breakthrough in genetic studies of animal domestication

April 21, 2010
Both of these chickens are eight weeks old but from a high-growth line and a low-growth line developed at Virginia Tech. The research team identified a gene found in all of Virginia Tech's high-growth chickens but few of the low-growth ones that appears to regulate appetite. Credit: Virginia Tech Photo

A Virginia Tech animal scientist, who in 1957 began breeding lines of White Plymouth Rock chickens based on their juvenile body weight, has provided scientists around the world with a model for exploring the molecular basis of traits like growth and reproduction - traits that molded the red jungle fowl into a farm animal roughly 8,000 years ago.

Paul Siegel, University Distinguished Professor Emeritus of Animal and Poultry Sciences in the College of Agriculture and Life Sciences, co-authored an article in the March 25 issue of the scientific journal Nature that uses data from his decades-long poultry selection project. The article, Whole-genome resequencing reveals loci under selection during chicken , highlights research at Uppsala University in Sweden and the Broad Institute of MIT and Harvard University.

"Throughout my career, I have been interested in studying the relationships between growth, reproduction, and immunology of ," said Siegel, who joined the Virginia Tech faculty in 1957.

In his first month on the job, Siegel designed an experiment that would create two flocks of a common breed of chickens: a high-growth line and a low-growth line. Every year, he bred the heaviest and lightest chickens with others of similar weight. Today, Siegel's high-growth chickens are nine times larger than the low-growth ones by the time they reach selection age, even though they both originated from the same flock.

"By selecting for growth, we are testing the genetic and immunological limits of poultry," Siegel explained.

In 2004, scientists completed the of the red jungle fowl - the same species as the . Researchers throughout the world began to search for that determine specific traits in broilers, layers, and red jungle fowl. This research has led to factors that have affected the chicken genome through domestication.

In addition to scanning the of common breeds of poultry, researchers looked at the extreme cases of the high- and low-growth chickens at Virginia Tech. According to Siegel, the decades of poultry breeding complete the recent advances in genome sequencing technology.

"The question becomes, 'Now that we have the technology, do we have the populations to support the use of the technology?' " Siegel said. "The answer is 'yes.' Not only do we at Virginia Tech have a population, we have the complete pedigree for 53 generations."

The research team identified a gene found in all of Virginia Tech's high-growth chickens but few of the low-growth ones that appears to regulate appetite - a finding that could have ramifications for both animal and human health studies involving weight. Previous research has shown that appetite, in addition to metabolism, plays a significant role in weight gain or loss in poultry.

The team is also investigating a gene that encodes the thyroid-stimulating hormone receptor protein to determine whether domestication altered the genetic makeup of chickens thousands of years ago. If true, this would be the first time that scientists have identified a mutation in animals caused by domestication.

Explore further: Darwin was wrong about the wild origin of the chicken

More information: www.nature.com/nature/journal/v464/n7288/full/nature08832.html

Related Stories

Darwin was wrong about the wild origin of the chicken

February 29, 2008

Charles Darwin maintained that the domesticated chicken derives from the red jungle fowl, but new research from Uppsala University now shows that the wild origins of the chicken are more complicated than that.

Recommended for you

Ten months in the air without landing

October 27, 2016

Common swifts are known for their impressive aerial abilities, capturing food and nest material while in flight. Now, by attaching data loggers to the birds, researchers reporting in the Cell Press journal Current Biology ...

1 comment

Adjust slider to filter visible comments by rank

Display comments: newest first

1 / 5 (1) Apr 21, 2010
Something similar was done at the University of Washington, Seattle, ca. 50 yrs ago w/ wild salmon but of course no genome reading. If I remember correctly they had the fish returning in 2 yrs at 2 to 3x the size of the wild population returning in 3 yrs. I don't know what happened to the experiment but it would be great to find out.

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.