Related topics: cells · protein · dna · genetic material · dna sequences

Extinct giant ape directly linked to the living orangutan

By using ancient protein sequencing, researchers have retrieved genetic information from a 1.9 million year old extinct, giant primate that used to live in a subtropical area in southern China. The genetic information allows ...

Fruit flies help in the development of personalized medicine

People with the same diagnosis typically receive a standard treatment that is not necessarily effective for everyone. With knowledge of the individual patient's genome, it may be possible in the future to a greater extent ...

Did microbes assist life in colonizing land?

All living organisms exist and function only in cooperation with an abundance of symbiotic microorganisms, and have developed together with them over the course of the earth's history. This central finding of modern life ...

Secret messages hidden in light-sensitive polymers

Scientists from the CNRS and Aix-Marseille Université have recently shown how valuable light-sensitive macromolecules are: When exposed to the right wavelength of light, they can be transformed so as to change, erase or ...

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DNA sequence

A DNA sequence or genetic sequence is a succession of letters representing the primary structure of a real or hypothetical DNA molecule or strand, with the capacity to carry information as described by the central dogma of molecular biology.

The possible letters are A, C, G, and T, representing the four nucleotide bases of a DNA strand — adenine, cytosine, guanine, thymine — covalently linked to a phosphodiester backbone. In the typical case, the sequences are printed abutting one another without gaps, as in the sequence AAAGTCTGAC, read left to right in the 5' to 3' direction. Short sequences of nucleotides are referred to as oligonucleotides and are used in a range of laboratory applications in molecular biology. With regard to biological function, a DNA sequence may be considered sense or antisense, and either coding or noncoding. DNA sequences can also contain "junk DNA."

Sequences can be derived from the biological raw material through a process called DNA sequencing.

In some special cases, letters besides A, T, C, and G are present in a sequence. These letters represent ambiguity. Of all the molecules sampled, there is more than one kind of nucleotide at that position. The rules of the International Union of Pure and Applied Chemistry (IUPAC) are as follows:

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