During the reprogramming of somatic cells back into stem cells, gene regulation is controlled by pioneer transcription factors. These bind to the tightly packaged DNA in order to make it accessible.
Molecular & Computational biology
Feb 26, 2024
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14
Gene regulatory networks (GRNs) depict the regulatory mechanisms of genes within cellular systems as a network, offering vital insights for understanding cell processes and molecular interactions that determine cellular phenotypes. ...
Molecular & Computational biology
Feb 23, 2024
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18
New international research shines a light on the role of transcription factors during early embryonic development. Transcription factors are proteins that are critical for gene regulation. The study unveiled more than 1,000 ...
Molecular & Computational biology
Feb 6, 2024
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3
Investigators from the laboratory of Ali Shilatifard, Ph.D., the Robert Francis Furchgott Professor and chair of Biochemistry and Molecular Genetics, have discovered a new repeat gene cluster sequence that is exclusively ...
Evolution
Nov 24, 2023
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260
In a recent article published in Molecular Cell, Ali Shilatifard, Ph.D., the Robert Francis Furchgott Professor and chair of Biochemistry and Molecular Genetics, and Yuki Aoi Ph.D., a postdoctoral fellow in Shilatifard laboratory, ...
Cell & Microbiology
Nov 3, 2023
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66
The different cell types of the human gut develop from stem cells through a process of differentiation. Researchers from the Organoid group (Hubrecht Institute), together with researchers at the Princess Máxima Center and ...
Cell & Microbiology
Oct 30, 2023
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35
Tomato (Solanum lycopersicum), one of the most important horticultural crops, is rich in iron and vitamins. As an essential micro-element for plants, iron (Fe) deficiency not only restricts tomato growth, development and ...
Molecular & Computational biology
Sep 25, 2023
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1
In eukaryotes, genomic DNA, which is a very long double helix containing all the genetic information, wraps around a globular protein called a histone and folds it many times before being contained within the nucleus.
Molecular & Computational biology
Sep 22, 2023
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1
The intricate interplay of gene expression within living cells is akin to a well-orchestrated symphony, with each gene playing its part in perfect harmony to ensure cells function as they should. At the heart of this symphony ...
Cell & Microbiology
Sep 19, 2023
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135
In plants, 5mC DNA methylation is an important and conserved epistatic mark involving genomic stability, gene transcriptional regulation, developmental regulation, abiotic stress response, metabolite synthesis, etc. However, ...
Molecular & Computational biology
Aug 29, 2023
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