Related topics: genes · cells · gene expression · stem cells · dna sequences

True love: How transcription factors interact to create a heart

Scientists at the Gladstone Institutes have discovered that three transcription factors—proteins that direct gene expression—interact with each other and the genome to influence how a heart forms in an embryo. Without ...

Turning the volume of gene expression up and down

Gene expression can be turned on and off like a switch, or it can be finely adjusted , as with a volume control knob. Dr Garth Ilsley, research scientist in Prof. Nick Luscombe's unit at the Okinawa Institute of Science and ...

Role model stem cells: How immune cells can self-renew

When our organs age or wear out, their renewal usually depends on a few stem cells in the tissue, because the vast majority of differentiated cells have lost their ability to divide and generate new cells. A German-French ...

Genetic traffic signal orchestrates early embryonic development

You are the product of metamorphosis. During the third week of your embryonic existence, fateful genetic choices were made that began to transform a tiny ball of identical stem cells into a complex organism of flesh and blood, ...

New insights into cooperativity in gene regulation

In a study published in Nature, Dirk Schübeler and his group at the Friedrich Miescher Institute for Biomedical Research (FMI) describe how the interplay between transcription factors and epigenetic modifications of DNA ...

Error correction strategies of cells: Team proposes new hypothesis

Cells dynamically respond to environmental signals by turning appropriate sets of genes on or off. The "control system" that determines which genes need to be expressed at what time depends primarily on the interactions between ...

Complex grammar of the genomic language

A new study from Sweden's Karolinska Institutet shows that the 'grammar' of the human genetic code is more complex than that of even the most intricately constructed spoken languages in the world. The findings, published ...

Scientists find cells rhythmically regulate their genes

Even in a calm, unchanging environment, cells are not static. Among other actions, cells activate and then deactivate some types of transcription factors—proteins that control the expression of genes—in a series of unpredictable ...

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