What makes one Argonaute a slicer and another one not? Human Argonaute proteins are key players in the gene regulation process known as RNA interference, RNAi. Professor Joshua-Tor's group of Cold Spring Harbor Laboratory ...
Cell & Microbiology
Jun 6, 2013
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Small RNA-based nucleic acid drugs represent a promising new class of therapeutic agents for silencing abnormal or overactive disease-causing genes, and researchers have discovered new mechanisms by which RNA drugs can control ...
Biotechnology
Feb 2, 2012
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Around a decade ago, an invasive fungal disease called myrtle rust reached Australia and began to spread like a plague through certain plants. The disease affects plants of the Myrtaceae family, which includes eucalypts, ...
Ecology
Dec 15, 2023
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Researchers have revealed the regulatory mechanism of a specific protein that plays a key role in balancing the immune response triggered by viral infections in mammal cells. These findings could help drive the development ...
Cell & Microbiology
Apr 18, 2024
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The application of a new, precise way to turn genes on and off within cells, described online October 9, 2014 in two articles in the journal Cell, is likely to lead to a better understanding of diseases and possibly to new ...
Cell & Microbiology
Oct 14, 2014
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Control of RNA lifespan is vital for the proper functioning of our cells. Marc Bühler's group at the Friedrich Miescher Institute for Biomedical Research (FMI) has discovered a novel mechanism determining the fate of RNA ...
Cell & Microbiology
Jun 5, 2017
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One of the most successful techniques to combat multidrug resistance in cancer cells is the downregulation of those genes responsible for drug resistance. Chinese scientists have now developed a nanoplatform that selectively ...
Biochemistry
Nov 21, 2018
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110
A recent study looking at the molecular foundation of myrtle rust reveals how the pathogen breaks into a host plant and how the host plant responds. This insight will inform the design of useful tools to prevent future break-ins ...
Molecular & Computational biology
Jul 5, 2024
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(Phys.org)—Bacteria may be simple creatures, but unlike "higher" organisms they have a neat evolutionary trick. When the going gets tough, they can simply pick up and incorporate a loose bit of genetic material from their ...
Cell & Microbiology
Aug 31, 2012
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The team of Johannes Zuber at the IMP in Vienna, Austria, managed to overcome remaining key limitations of RNA interference (RNAi) - a unique method to specifically shut off genes. By using an optimized design, the scientists ...
Cell & Microbiology
Dec 13, 2013
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