Chimeric viruses unearth hidden gems in dengue virus structure

In a recent study, Australian scientists used an original approach to resolve the 3D structure of flaviviruses with an unprecedented level of detail, identifying small molecules known as 'pocket factors' as new therapeutic ...

New insights into switchable MOF structures

Metal-organic framework compounds (MOFs) consist of inorganic and organic groups and are characterized by a large number of pores into which other molecules can be incorporated. MOFs are therefore interesting for many applications, ...

Cell cytoskeleton as target for new active agents

Through a unique combination of computer simulations and laboratory experiments, researchers at the Paul Scherrer Institute (PSI) have discovered new binding sites for active agents—against cancer, for example—on a vital ...

How nitrate regulates gene expression in legumes

Plants in the bean family (legumes) form nodules on their roots to take up nitrogen. Legumes will stop nodule production when nitrogen is plentiful (Figure 1), but precisely how nitrate presence controls nodule formation ...

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