Hook-on drugs: New delivery strategy for K-Ras disruption

"The strategy was to design the drug to be able to hook into the hole of the FTase and GGTase I, otherwise the surface of the proteins are too large and slippery," Dr. Junko Ohkanda of Shinshu University explains her strategy ...

Capturing extreme close-ups of cellular gene expression

Scientists studying genetic transcription are gaining new insights into a process that is fundamental to all life. Transcription is the first step in gene expression, the process taking place within all living cells by which ...

Study probes interplay of proteins in type 2 diabetes

A hallmark of age-related diseases such as Parkinson's disease, type 2 diabetes, or Alzheimer's disease is the abnormal clumping of proteins in cells. In people with these conditions, these protein clumps can result in irregular ...

Decoding messages in the body's microscopic metropolises

A study aimed at identifying and examining the small messenger proteins used by microbes living on and inside humans has revealed an astounding diversity of more than 4,000 families of molecules – many of which have never ...

Blue light for RNA control

Messenger RNA molecules contain genetic information and thus control the synthesis of proteins in living cells. Biochemists at the University of Bayreuth and the University of Bonn have now discovered a way to regulate this ...

New software brings lower-resolution cryo-EM maps into focus

Cryo-electron microscopy is now the most popular method for determining protein structures, which helps researchers develop drugs for different kinds of ailments. Over the last several decades, it has replaced X-ray crystallography ...

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