Plants lack eyes and ears, but they can still see, hear, smell and respond to environmental cues and dangers—especially to virulent pathogens. They do this with the aid of hundreds of membrane proteins that can sense microbes ...
Plants & Animals
Jan 19, 2018
0
1870
Researchers at the University of British Columbia have identified a common ancestral gene that enabled the evolution of advanced life over a billion years ago.
Evolution
Mar 3, 2016
10
956
Constant exposure of cells to stressing agents, such as pathogens, may disturb an organism's normal functioning. To fight stress, cells have developed several coping mechanisms, including the inflammatory response.
Molecular & Computational biology
Sep 14, 2023
0
142
For a long time it has been known that the protein TOR - Target of Rapamycin - controls cell growth and is involved in the development of diseases such as cancer and diabetes. Researchers at the University of Basel's Biozentrum ...
Biochemistry
Dec 17, 2015
0
57
A new technique that will allow scientists to determine the effects of turning on and off a set of molecules involved in almost every cellular pathway, determine their downstream effects, and uncover new drug targets has ...
Biochemistry
Dec 13, 2016
0
395
When cells in the human body sense a change in the environment, molecules known as kinases can help them respond: these specialized enzymes activate proteins, propagating signals within a cell that ultimately alter its function. ...
Biochemistry
Feb 18, 2023
0
23
Two studies led by UT Southwestern researchers shed light on the biology and potential vulnerabilities of schistosomes—parasitic flatworms that cause the little-known tropical disease schistosomiasis. The findings, published ...
Cell & Microbiology
Sep 24, 2020
0
147
The human cellular kinome contains over 500 kinases, accounting for almost 2% of all our genes. It is currently impossible to gauge the phosphorylation status, or even phosphorylation potential, of the entire proteome of ...
University of Leicester researchers have shed new light on how bacteria sense nutrients in their environment—which could provide important knowledge in the development of drugs and antibiotics to combat a range of diseases ...
Cell & Microbiology
Aug 3, 2018
0
28
Better treatments for some of cancer's deadliest forms could be closer due to a University of California, Irvine-led discovery about how a certain protein is activated in tumor cells. The finding, spearheaded by researchers ...
Cell & Microbiology
Jul 18, 2022
0
73
A protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation). Phosphorylation usually results in a functional change of the target protein (substrate) by changing enzyme activity, cellular location, or association with other proteins. The human genome contains about 500 protein kinase genes and they constitute about 2% of all human genes. Protein kinases are also found in bacteria and plants. Up to 30% of all human proteins may be modified by kinase activity, and kinases are known to regulate the majority of cellular pathways, especially those involved in signal transduction.
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