Protein kinases, most scientists would agree, regulate nearly every aspect of cell life. It is no surprise, then, that having faulty protein kinases may lead to a number of human conditions, including cardiovascular diseases, ...
Biochemistry
Apr 8, 2016
0
298
Cells continuously replicate to repair and replace damaged tissue, and each division requires duplicating DNA. As the DNA duplicates, errors inevitably occur, resulting in damage that, if left unrepaired, can lead to cellular ...
Cell & Microbiology
Dec 1, 2017
0
301
Researchers from Aarhus University challenge one of the cornerstones of biochemistry, the Michaelis-Menten equation. They show that many enzymes in signaling pathways are independent of substrate concentration, because the ...
Biochemistry
Aug 20, 2020
0
375
Based on research that reveals new insight into mechanisms that allow invasive tumor cells to move, researchers at the Mayo Clinic campus in Florida have a new understanding about how to stop cancer from spreading. A cancer ...
Cell & Microbiology
Mar 29, 2009
0
0
A collaborative study from UT Southwestern scientists has identified a new function for a protein called TAO2 that appears to be key to inhibiting replication of the influenza virus, which sickens millions of individuals ...
Cell & Microbiology
Jun 20, 2022
0
278
A team of researchers affiliated with several institutions in South Korea has found that stimulating production of a certain enzyme in roundworms can increase their lifespan. In their paper published in the journal Science ...
Direct observations of the structure and catalytic mechanism of a prototypical kinase enzyme—protein kinase A or PKA—will provide researchers and drug developers with significantly enhanced abilities to understand and ...
Biochemistry
Mar 20, 2019
0
186
In order for tumors to successfully take hold and spread in the body, they typically must meet several developmental milestones. These include things like suppressing apoptosis, cultivating replication and angiogenesis, weaning ...
A University of Utah-led study using X-rays and neutron beams has revealed the inner workings of a master switch that regulates basic cellular functions, but that also, when mutated, contributes to cancer, cardiovascular ...
Biochemistry
Oct 9, 2014
0
0
The post-translational addition of phosphate groups to serine, threonine and tyrosine residues is a fundamental strategy for regulating protein activities in eukaryotes. Eukaryotic protein kinases—the enzymes that catalyze ...
Cell & Microbiology
Jul 17, 2018
0
6
