Stimulating production of enzyme in roundworms found to increase lifespan
A team of researchers affiliated with several institutions in South Korea has found that stimulating production of a certain enzyme in roundworms can increase their lifespan. In their paper published in the journal Science Advances, the group describes their study of the protein VRK-1 and what they learned about its impact on the longevity of roundworms.
Prior research has shown that one way to increase longevity in some species is to use techniques that slow down mitochondrial respiration. In this new effort, the researchers were looking to better understand why slowing energy use in mitochondria has an impact on aging. As part of their effort, they looked at an energy sensor in mitochondria called adenosine 5'-monophosphate-activated protein kinase (AMPK), known to play a role in controlling how much energy is used in cells in roundworms. Prior research had suggested its level of activity is controlled by the protein VRK-1. To learn more about its impact on aging, the researchers genetically engineered two lines of roundworms to force them to produce more VRK-1 and two lines of roundworms to force them to produce less VRK-1. They then monitored the roundworms to see how long they lived.
The researchers found those roundworms expressing more than the normal amount of VRK-1 tended to live longer than average, while those expressing less than average amounts of VRK-1 had shorter lifespans. More specifically, control worms representing the normal lifespan of a roundworm lived on average 16.9 days. In their experiments, one of the lines expressing more VRK-1 lived on average 20.8 days, while the other lived on average 23.7 days. And one of the lines producing less VRK-1 lived on average just 12.7 days and the other just 15.9 days. The researchers suggest this finding indicates that VRK-1 has a direct impact on roundworm longevity.
The researchers next tried activating AMPK in human cells using the human equivalent of VRK-1 and found that AMPK was activated similarly to the ways it was activated in roundworms. They suggest it is possible that this discovery could increase the human lifespan. They note that much more testing is required, starting with other mammals, before it can be determined if therapies to force more production of VRK-1 might be used to extend human lifespans.
More information: Sangsoon Park et al. VRK-1 extends life span by activation of AMPK via phosphorylation, Science Advances (2020). DOI: 10.1126/sciadv.aaw7824
Journal information: Science Advances
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