How to kill a protein
For decades scientists have been looking closely at how our cells make proteins. But the inverse is equally important: how cells kill them.
Cell & Microbiology
Apr 24, 2015
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Page 3 - News tagged with proteasome
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Scientists gain new insights into protein disposal
Cells have a sophisticated system to control and dispose of defective, superfluous proteins and thus to prevent damage to the body. Dr. Katrin Bagola and Professor Thomas Sommer of the Max Delbrück Center for Molecular Medicine ...
Cell & Microbiology
May 28, 2013
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Assembly of a protein degradation machine could lead to treatments in cancer, neurological diseases
Kansas State University scientists helped discover new details about an intricate process in cells. Their finding may advance treatments for cancer and neurological diseases.
Cell & Microbiology
May 6, 2013
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Scientists discover new way protein degradation is regulated
(Phys.org) —Proteins, unlike diamonds, aren't forever. And when they wear out, they need to be degraded in the cell back into amino acids, where they will be recycled into new proteins. Researchers at Rockefeller University ...
Cell & Microbiology
Apr 26, 2013
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Stem cells: Keeping differentiation in check
Researchers at the A*STAR Institute of Medical Biology (IMB) have discovered a critical checkpoint protein that controls when human embryonic stem cells (hESCs) begin to differentiate.
Cell & Microbiology
Feb 27, 2013
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Accelerating the tempo of the segmentation clock by reducing the number of introns in the Hes7 gene
Somites, precursors for the segmental structures such as the vertebral column, ribs and skeletal muscles, form periodically by segmentation of the rostral parts of the presomitic mesoderm (PSM). This periodic event is regulated ...
Cell & Microbiology
Jan 9, 2013
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Watching the cogwheels of the biological clock in living cells
Our master circadian clock resides in a small group of about 10'000 neurons in the brain, called the suprachiasmatic nucleus. However, similar clocks are ticking in nearly all cells of the body, as demonstrated by the group ...
Cell & Microbiology
Oct 26, 2012
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Making a molecular micromap: Imaging the yeast 26S proteasome at near-atomic resolution
(Phys.org)—Biological systems are characterized by a form of molecular recycling – and proteins do not escape this fate. In particular, unneeded or damaged proteins biochemically marked for destruction undergo controlled ...
Immunoproteasome crystal structure determined
Like a shredder, the immunoproteasome cuts down proteins into peptides that are subsequently presented on the cellular surface. The immune system can distinguish between self and nonself peptides and selectively kills cells ...
Biochemistry
Feb 16, 2012
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How cells dispose of their waste
German researchers reveal the structure of cellular protein degradation machinery.
Cell & Microbiology
Jan 23, 2012
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