A protein complex called facilitates chromatin transcription (FACT) plays a role in DNA packing within a nucleus, as well as in oncogenesis. A team of scientists from MSU, working in cooperation with foreign colleagues, have ...
Cell & Microbiology
May 28, 2018
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Chromatin remodelers are needed to take nucleosomes away from DNA in order to make room for transcription factors to bind, and regulate the activity of our genes. It has been unclear how dynamic this process is. Researchers ...
Evolution
Feb 9, 2021
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How can proteins bind DNA in the cell nucleus, where it is present in form of chromatin, tightly wrapped around histones and therefore mostly inaccessible? Recently, several studies began to uncover the various strategies ...
Cell & Microbiology
Jun 29, 2021
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Blood cells originate from a small pool of hematopoietic stem cells (HSCs) through a complex process of differentiation steps that are tightly regulated at the transcriptional level. Dissecting the mechanisms underlying this ...
Cell & Microbiology
Oct 5, 2012
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In eukaryotic cells, linear genetic DNA wraps around histones to form stable nucleosomes that further assemble to form chromatins. Nucleosomes represent big barriers to the transcription machine RNA polymerase.
Cell & Microbiology
Jul 23, 2018
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Accessing DNA wrapped into basic units of packaging, called nucleosomes, depends on the underlying sequence of DNA building blocks, or base pairs. Like Christmas presents, some nucleosomes are easier to unwrap than others. ...
Biotechnology
Dec 5, 2017
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Researchers at Colorado State University have developed a new imagining technique that shows key cellular interactions over time and space in a way that was not previously possible. The work could one day help in efforts ...
Cell & Microbiology
Oct 10, 2023
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Mayo Clinic researchers have shown that a molecule called Cul4 helps to deposit DNA-packaging histone proteins onto DNA, an integral step in cramming yards of genetic code into compact coils that can fit into each cell. When ...
Cell & Microbiology
Nov 7, 2013
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Chinese scientists reported the first high-resolution cryo-EM structure of human Polycomb repressive deubiquitinase (PR-DUB) complex bound to the chromatosome particle with mono-ubiquitinated H2AK119 (H2AK119ub1), revealing ...
Cell & Microbiology
Mar 30, 2023
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2
Northwestern Medicine scientists have developed a new method to analyze the protein composition of intact nucleosomes without losing combinatorial information present in chromatin. The technique, called Nuc-MS, could help ...
Biotechnology
May 24, 2021
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