The way DNA folds largely determines which genes are read out. John van Noort and his group have quantified how easily rolled-up DNA parts stack. This costs less energy than previously assumed. Publication in Biophysical ...
Biochemistry
Nov 12, 2018
0
23
LMU researchers have, for the first time, systematically determined the positioning of the packing units of the fruit fly genome and discovered a new protein that defines their relationship to the DNA sequence.
Plants & Animals
Nov 5, 2018
0
11
A team of researchers at the University of Utah has found that nucleosomes can inhibit CRISPR/Cas9 cleavage efficiency. In their paper published in Proceedings of the National Academy of Sciences, the group describes testing ...
In the cell nucleus, the genomic DNA is packaged into a tightly condensed form, which is referred to as chromatin. The basic unit of chromatin organization is the nucleosome, a DNA-protein complex consisting of a defined ...
Cell & Microbiology
Sep 4, 2018
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11
In eukaryotic cells, linear genetic DNA wraps around histones to form stable nucleosomes that further assemble to form chromatins. Nucleosomes represent big barriers to the transcription machine RNA polymerase.
Cell & Microbiology
Jul 23, 2018
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11
A new method allows researchers to systematically identify specialized proteins that unpack DNA inside the nucleus of a cell, making the usually dense DNA more accessible for gene expression and other functions. The method, ...
Cell & Microbiology
Jul 12, 2018
2
128
A protein complex called facilitates chromatin transcription (FACT) plays a role in DNA packing within a nucleus, as well as in oncogenesis. A team of scientists from MSU, working in cooperation with foreign colleagues, have ...
Cell & Microbiology
May 28, 2018
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6
Until human genes are activated, they are blocked by structures known as nucleosomes, components that serve to package DNA inside cells.
Biotechnology
May 14, 2018
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144
DNA is tightly packed into the nucleus of a cell. Nevertheless, the cellular machinery needs to constantly access the genomic information. An LMU team now reveals the inner workings of a molecular motor made of proteins which ...
Cell & Microbiology
Apr 12, 2018
6
69
In cells, proteins tightly package the long thread of DNA into pearl necklace-like complexes known as chromatin. Scientists at EPFL show for the first time how chromatin moves, answering longstanding questions about how its ...
Cell & Microbiology
Jan 18, 2018
0
21
