A protein has been discovered that may have a profound effect on cholesterol metabolism. That discovery raises the possibility that the protein, dubbed IDOL, could be a powerful target for cholesterol-lowering drugs, says ...
Cell & Microbiology
May 17, 2011
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0
Humans with a high cholesterol fear the "bad cholesterol"—the so-called low-density lipoprotein (LDL)—because it is genetic and cannot be regulated with medication. However, a healthy occurrence of LDL is important for ...
Molecular & Computational biology
Oct 8, 2020
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4
PON1 (paraoxonase 1), an enzyme associated with high-density lipoprotein (HDL), breaks down lipid peroxides, highly reactive fatty molecules that can damage blood vessels.
Biochemistry
Aug 20, 2021
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288
High-density lipoprotein (HDL) is widely thought to protect against the development of atherosclerosis, yet drugs that raise levels of HDL cholesterol (HDL-C) have failed to reduce the risk of heart disease.
Biochemistry
Jul 2, 2018
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8
Efforts to explore the landscape of small RNAs (sRNAs)—short RNA molecules that are poorly understood—often use high-throughput sequencing (sRNA-seq). These efforts are hampered by a lack of tools to identify, quantify ...
Biotechnology
Sep 7, 2018
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3
After decades of work with no success, researchers have determined the high-resolution, three-dimensional structure for lipoprotein lipase, the enzyme that processes fats, or triglycerides, in the bloodstream and releases ...
Biochemistry
Feb 26, 2019
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18
Longitudinal studies of disease require collecting biofluids, preferentially blood. But getting serum blood samples takes the work of a professional, and storing thousands of such samples at -80 degrees C means using a lot ...
Analytical Chemistry
Jul 26, 2017
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1
