Scavengers "protect" HDL

July 2, 2018, Vanderbilt University

High-density lipoprotein (HDL) is widely thought to protect against the development of atherosclerosis, yet drugs that raise levels of HDL cholesterol (HDL-C) have failed to reduce the risk of heart disease.

Recent evidence suggests that HDL function is more important than HDL-C levels in lowering risk. Isolevuglandins (IsoLGs) are lipid molecules generated indirectly by the oxidative enzyme MPO that can bind irreversibly with proteins to modify their functions.

Now Linda May-Zhang, Ph.D., Sean Davies, Ph.D., and colleagues have shown that levels of IsoLG bound to HDL are higher in patients with high cholesterol compared to healthy controls and that binding of IsoLG degrades HDL function.

They also show that PPM, a small molecule "scavenger" they developed can block MPO-induced modification of HDL.

Their findings, published this month in the Journal of Biological Chemistry, suggest that modification of HDL proteins plays a major role in the development of atherosclerosis, and that scavengers such as PPM potentially could lower disease risk by preventing HDL dysfunction.

Explore further: Patients with high lipoprotein(a) levels may benefit from taking PCSK9 inhibitors

More information: Linda S. May-Zhang et al. Modification by isolevuglandins, highly reactive γ-ketoaldehydes, deleteriously alters high-density lipoprotein structure and function, Journal of Biological Chemistry (2018). DOI: 10.1074/jbc.RA117.001099

Related Stories

PCSK9 inhibitors have unexpected anti-inflammatory effects

April 6, 2018

PCSK9 inhibition is a new therapeutic strategy for atherosclerosis which is known to lower LDL cholesterol. Research from Karolinska Institutet, presented at the ESC Congress last year and now published in the Journal of ...

Back to basics for heart health

February 2, 2018

As heart month kicks off, doctors at Baylor College of Medicine say the first step to taking control of your health and preventing cardiovascular disease is understanding the basics and what they represent for your heart.

Recommended for you

New battery gobbles up carbon dioxide

September 21, 2018

A new type of battery developed by researchers at MIT could be made partly from carbon dioxide captured from power plants. Rather than attempting to convert carbon dioxide to specialized chemicals using metal catalysts, which ...

Scientists solve the golden puzzle of calaverite

September 21, 2018

Scientists from Russia and Germany have shed light on the crystalline structure of calaverite, foretelling the existence of a new gold compound previously unknown to chemists. The results of their study were published in ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.