Lysosome to mitochondria communication regulates longevity

As people get older, they often feel less energetic, mobile or active. This may be due in part to a decline in mitochondria, the tiny powerhouses inside of our cells, which provide energy and regulate metabolism. In fact, ...

Harnessing the moonseed plant's chemical know-how

In overgrown areas from Canada to China, a lush, woody vine with crescent-shaped seeds holds the secret to making a cancer-fighting chemical. Now, Whitehead Institute researchers in Member Jing-Ke Weng's lab have discovered ...

Researchers map protein motion

Cornell structural biologists took a new approach to using a classic method of X-ray analysis to capture something the conventional method had never accounted for: the collective motion of proteins. And they did so by creating ...

Simple single-step N-terminal modification of proteins

Proteins are widely used in medicine, biology and chemistry. Enhancing their inherent properties by adding functional molecules to their structures is a common and important step in many fields. For example, adding fluorescent ...

Team solves structure of key mTORC1 activator

A research team led by scientists at the Whitehead Institute has described the structure of a key protein complex that helps activate mTORC1, a master growth regulator that enables cells to quickly respond to changing nutrient ...

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