In nature, organic molecules are either left- or right-handed, but synthesizing molecules with a specific "handedness" in a lab is hard to do. Make a drug or enzyme with the wrong "handedness," and it just won't work. Now ...
Analytical Chemistry
Jan 10, 2024
0
100
For decades, a substantial number of proteins, vital for treating various diseases, have remained elusive to oral drug therapy. Traditional small molecules often struggle to bind to proteins with flat surfaces or require ...
Biochemistry
Dec 28, 2023
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203
People with chronic pain are often dependent on drugs from the class of opioids with sometimes considerable side effects. Accordingly, in recent years the search for safer alternatives has been the focus of new drug discovery.
Biochemistry
Dec 6, 2023
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20
Exploring the biomedical interactions for chemical compounds and protein targets is crucial for drug discovery. Determining these drug–drug interactions (DDI) and drug–target interactions (DTI) not only reveals the potential ...
Molecular & Computational biology
Dec 5, 2023
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23
Researchers report in the journal Nature that they have found a way to get antibacterial drugs through the nearly impenetrable outer membrane of Pseudomonas aeruginosa, a bacterium that—once it infects a person—is notoriously ...
Cell & Microbiology
Nov 22, 2023
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15
Under the ocean's surface, marine organisms are constantly releasing invisible molecules. Some of the chemical clues reveal which creatures are nearby, while others could be used someday as medications.
Biochemistry
Nov 8, 2023
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4
Separating molecules is critical to producing many essential products. For example, in petroleum refining, the hydrocarbons—chemical compounds composed of hydrogens and carbons—in crude oil are separated into gasoline, ...
Materials Science
Sep 10, 2023
2
110
Researchers at the Icahn School of Medicine at Mount Sinai have identified the structure of a special transporter found in red blood cells and how it interacts with drugs. Details on the findings, which were reported in the ...
Molecular & Computational biology
Sep 7, 2023
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81
Phenanthridines are heterocyclic compounds consisting of two six-membered benzene rings fused to a six-membered ring containing nitrogen. They are found in many naturally occurring organic compounds known for their anticancer ...
Analytical Chemistry
Jun 26, 2023
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2
A team of chemists and material scientists at the University of Tokyo has developed a new class of interlocking supramolecular systems by combining metal-organic frameworks with rotaxanes. In their study, reported in the ...
