New chemistry makes 'magic' drug improvements easier

In the last decade, scientists discovered a quirk of drug chemistry: If you add on a simple one-carbon building block to a drug, it can make the drug more potent, less toxic, or more stable.

Direct cloning method CAPTUREs novel microbial natural products

Microorganisms possess natural product biosynthetic gene clusters (BGCs) that may harbor unique bioactivities for use in drug development and agricultural applications. However, many uncharacterized microbial BGCs remain ...

New drug inhibits the growth of cancer cells

A newly developed compound starves cancer cells by attacking their "power plants"—the so-called mitochondria. The new compound prevents the genetic information within mitochondria from being read. Researchers from the Max ...

Algae breathe life into 3-D engineered tissues

3-D bioprinted algae can be harnessed as a sustainable source of oxygen for human cells in engineered vascularized tissues, researchers report November 18 in the journal Matter. They embedded the bioprinted photosynthetic ...

Divergent synthesis of bicyclic medium-sized ring structures

National University of Singapore chemists have discovered catalyst-controlled divergent reactions to synthesize three different classes of medium-sized bicyclic compounds from the same starting materials for the development ...

Novel antiviral strategy for treatment of COVID-19

A research team led by Professor Hongzhe SUN, Norman & Cecilia Yip Professor in Bioinorganic Chemistry, Department of Chemistry, Faculty of Science, and Professor Kwok Yung YUEN, Henry Fok Professor in Infectious Diseases, ...

Pharma aims to make a better CBD

Cannabidiol (CBD) is an increasingly popular wellness trend. The compound, which occurs naturally in cannabis plants, is added to many products that claim to reduce anxiety, alleviate pain and more, without the intoxication ...

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