Structural insight into process of gene regulation

In the cell nucleus, numerous proteins bind to the DNA molecule in order to regulate the activity of certain genes. One of these is the TATA-box binding protein (TBP), which binds to a specific DNA sequence and constitutes ...

Researchers identify gene mutation capable of regulating pain

Pain afflicts at least 1.5 billion people worldwide, and despite the availability of various painkilling drugs, not all forms of pain are treatable. Moreover, pain medications can have side-effects such as dependence and ...

New insights into centromere structure

Researchers led by Osaka University used cryogenic electron microscopy to analyze the atomic structure of the centromeric region of the chromosome, essential for cell division. A protein called CENP-A marks the centromere; ...

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