Gatekeepers of the genome
Transcription factors control gene activation in cells. By binding to specific segments of DNA, they enable the blueprints that code for cellular proteins to be produced. But how are such factors themselves regulated?
Transcription factors control gene activation in cells. By binding to specific segments of DNA, they enable the blueprints that code for cellular proteins to be produced. But how are such factors themselves regulated?
Cell & Microbiology
Jul 30, 2019
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7
Membranes composed of a lipid bilayer define the outer surface of nucleated cells (the plasma membrane) and delimit the vital organelles within these cells, such as mitochondria and nuclei. The membrane curvature determines ...
Cell & Microbiology
Jul 24, 2019
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30
A new mechanism for the deactivation of switch proteins has been identified by researchers from Ruhr-Universität Bochum, headed by Professor Klaus Gerwert and Dr. Till Rudack from the Department of Biophysics, and the University ...
Biochemistry
Jul 22, 2019
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36
A team led by a Baylor University researcher has published a breakthrough article that provides a better understanding of the dynamic process by which sunlight-induced DNA damage is recognized by the molecular repair machinery ...
Molecular & Computational biology
Jul 14, 2019
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343
When mitochondria become damaged, they avoid causing further problems by signaling cellular proteins to degrade them. In a paper publishing April 11, 2019, in the journal Developmental Cell, scientists in Norway report that ...
Cell & Microbiology
Apr 11, 2019
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664
The working group under Junior Professor Dr. Mathias Beller from the University of Düsseldorf has analyzed the function of a lipid droplet-associated protein. They used fruit flies to demonstrate that the protein has a major ...
Cell & Microbiology
Mar 26, 2019
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67
Protein nanomachines made of multiple protein molecules are highly dynamic during their actions on their functional targets, sometime called substrates. Dynamics of these large protein nanomachines of more than megadalton ...
Biochemistry
Feb 26, 2019
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7
Researchers at the University of Helsinki uncovered the mechanisms for a novel cellular stress response arising from the toxicity of newly synthesized proteins. Activation of the stress response is at the epicentre of the ...
Cell & Microbiology
Feb 22, 2019
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2
Though separated by a world of ocean, and unrelated to each other, two fish groups—one in the Arctic, the other in the Antarctic—share a surprising survival strategy: They both have evolved the ability to produce the ...
Biotechnology
Feb 11, 2019
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210
Researchers from the National Institute of Chemistry in Slovenia have developed a novel approach to regulate human cell response, endowing cells to respond to extracellular stimuli in minutes instead of hours. The authors ...
Cell & Microbiology
Jan 28, 2019
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3