Atomic picture of dengue replication could transform antiviral approaches
A detailed atomic exploration into how the dengue virus replicates its genome could catalyze the development of high-precision targeted antiviral therapeutics.
A detailed atomic exploration into how the dengue virus replicates its genome could catalyze the development of high-precision targeted antiviral therapeutics.
Cell & Microbiology
Oct 31, 2023
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1
Fluorescence-guided intervention strategies can improve standard therapies to detect and treat microscopic tumors to thereby prevent lethal recurrence. Cancer biologists have made tremendous progress in photoimmunotherapy ...
Azobenzenes are incredibly versatile and have many potential uses, such as in making tiny machines and improving technology as well as making light controllable drugs. This molecule can switch between two different forms ...
Biochemistry
Sep 21, 2023
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167
To make a gene-editing tool more precise and easier to control, Rice University engineers split it into two pieces that only come back together when a third small molecule is added.
Biotechnology
Sep 21, 2023
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22
Vibrant green leaves sprout from tall fragrant plants sitting neatly in two rows of terracotta pots in Valerie Sponsel's UTSA biology laboratory. One floor just above her is the chemistry lab of Francis Yoshimoto, who is ...
Biochemistry
Sep 8, 2023
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161
Chemotherapy is a mainstay of cancer treatment. While effective, this therapy indiscriminately kills rapidly dividing cells—cancerous or otherwise—so patients frequently experience severe side effects, ultimately limiting ...
Bio & Medicine
Aug 9, 2023
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18
Rhomboid proteases are a promising target for new drugs. Now researchers from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) have uncovered a mechanism for regulating enzyme activity. The key role is played ...
Cell & Microbiology
Jul 21, 2023
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48
Many diseases can be successfully treated in the simple environment of a cell culture dish, but to successfully treat real people, the drug agent has to take a journey through the infinitely more complex environment within ...
Bio & Medicine
Jul 17, 2023
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In drug delivery, the therapeutic behavior of the nanocarriers is limited by the "foreign" character of their surface. Despite the wide range of sophisticated coatings available, immune cells often identify these synthetic ...
Bio & Medicine
Jul 13, 2023
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31
Researchers at the University of Helsinki, together with researchers from the United States, have discovered a small molecule that inhibits the formation in cells of cytokine proteins that promote inflammation. The mechanism ...
Biochemistry
Jun 7, 2023
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40