This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility:


peer-reviewed publication

trusted source


Electrochemistry converts carbon to useful molecules

Carbon dioxide
Ball-and-stick model of carbon dioxide. Credit: Wikipedia

A chemistry collaboration has led to a creative way to put carbon dioxide to good—and even healthy—use: by incorporating it, via electrosynthesis, into a series of organic molecules that are vital to pharmaceutical development.

In the process, the research team made an innovative discovery. By changing the type of electrochemical reactor, they could produce two completely different products, both of which are useful in .

The team's paper, "Electrochemical Reactor Dictates Site Selectivity in N-Heteroarene Carboxylations," published Jan 5 in Nature. The paper's co-lead authors are postdoctoral researchers Peng Yu and Wen Zhang, and Guo-Quan Sun of Sichuan University in China.

The Cornell team, led by Song Lin, professor of chemistry and chemical biology in the College of Arts and Sciences, has previously used the process of electrochemistry to stitch together simple molecules and form complex compounds, eliminating the need for precious metals or other catalysts to promote the chemical reaction.

For the new project, they set their sights on a more specific target: , the second-most prevalent heterocycle in FDA-approved drugs. Heterocyles are in which the molecules' atoms are linked into ring structures, at least one of which is not carbon. These structural units are considered to be "pharmacophores" for their frequent presence in medicinally active compounds. They are also commonly found in agrochemicals.

The researchers' goal was to make carboxylated pyridines, i.e., pyridines with appended to them. The advantage of introducing carbon to a pyridine ring is that it can change a molecule's functionality and potentially help it bind to certain targets, such as proteins. However, the two molecules are not natural partners. Pyridine is a reactive molecule, while carbon dioxide is generally inert.

"There are very few ways of directly introducing carbon dioxide to a pyridine," said Lin, the paper's co-senior author, along with Da-Gang Yu of Sichuan University. "The current methods have very severe limitations."

Lin's lab combined its expertise in with Yu's group's specialization in utilizing carbon dioxide in organic synthesis, and they were able to successfully create carboxylated pyridines.

"Electrochemistry gives you that leverage to dial in the potential that is sufficient to activate even some of the most inert molecules," Lin said. "That's how we were able to achieve this reaction."

The team's serendipitous discovery emerged while they were conducting the electrosynthesis. Chemists typically run an electrochemical reaction in one of two ways: in an undivided electrochemical cell (in which the anode and cathode that supply the are in the same solution) or in a divided electrochemical cell (whereby the anode and cathode are separated by a porous divider that blocks large organic molecules but allows ions to pass through). One approach may be more efficient than the other, but they both produce the same product.

Lin's group found that by switching from a divided to an undivided cell they could selectively attach the carbon dioxide molecule on different positions of the pyridine ring, creating two different products: C4-carboxylation in the undivided cell and C5-carboxylation in the divided cell.

"This is the first time we discovered that by just simply changing the cell, what we call the electrochemical reactor, you completely change the product," Lin said. "I think that mechanistic understanding of why it happened will allow us to continue to apply the same strategy to other molecules, not just pyridines, and maybe make other in this selective but controlled fashion. I think that's a general principle that can be generalized to other systems."

While the project's form of carbon dioxide utilization is not going to solve the global challenge of climate change, Lin said, "it's a small step towards using excessive carbon dioxide in a useful way."

Co-authors included postdoctoral researcher Yi Wang and doctoral student Zhipeng Lu; and researchers from Sichuan University.

More information: Guo-Quan Sun et al, Electrochemical reactor dictates site selectivity in N-heteroarene carboxylations, Nature (2023). DOI: 10.1038/s41586-022-05667-0

Journal information: Nature

Provided by Cornell University

Citation: Electrochemistry converts carbon to useful molecules (2023, January 5) retrieved 26 March 2023 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

100% efficient electrochemical conversion of carbon dioxide


Feedback to editors