Chemists use light energy to produce small molecular rings

Chemists use light energy to produce small molecular rings
Single-crystal X-ray structures of two products arising from the cycloaddition reaction. In particular, on the left a unique five-four-three membered condensed ring system is visible. On the right, a four-six membered framework can be recognized. Carbon atoms are shown in grey, hydrogen atoms in white, nitrogen atoms in blue, oxygen atoms in red and chlorine atoms in green. Credit: University of Münster - Peter Bellotti

In the search for new active agents in medicine, molecules whose atoms are linked in rings are becoming increasingly important. Such ring systems have particularly suitable properties for producing such active agents and they are driving the development of innovative treatments for malignant tumours, as well as for neurodegenerative and infectious diseases. A team of chemists headed by Prof. Frank Glorius from the University of Münster has now succeeded in synthesising new and medically significant small molecular rings, which are difficult to produce because they are particularly sensitive. The team's work has been published in the journal Nature Catalysis.

Among chemists, especially the synthesis of small ring systems from so-called aromatic compounds is considered to be difficult. Also, an especially large amount of energy is needed for the process. A further hurdle is that the energy has to be released selectively to the source materials, but not to the heat-sensitive products. Frank Glorius' team has now developed a strategy in which , as an inexpensive energy source, activates a photocatalyst which drives the reaction. The photocatalyst absorbs the light and transfers its energy to the source materials. In this way, it enables synthesis to take place which is highly efficient and mild and which has no, or hardly any, undesired side-reactions.

"We see our study as a breakthrough in synthesis chemistry," says lead author Dr. Jiajia Ma. "It shows that can be used in a targeted way to produce small ring systems. The fact that, by using different reaction partners, we can produce different ring systems provides numerous opportunities for the production of active agents." For their source materials, the used only easily available, inexpensive raw materials.


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More information: Jiajia Ma et al, Facile access to fused 2D/3D rings via intermolecular cascade dearomative [2 + 2] cycloaddition/rearrangement reactions of quinolines with alkenes, Nature Catalysis (2022). DOI: 10.1038/s41929-022-00784-5
Journal information: Nature Catalysis

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Citation: Chemists use light energy to produce small molecular rings (2022, May 26) retrieved 27 June 2022 from https://phys.org/news/2022-05-chemists-energy-small-molecular.html
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