Toxic masculinity: Y chromosome contributes to a shorter lifespan in male flies

Toxic masculinity: Y chromosome contributes to a shorter lifespan in male flies
Heterochromatin enrichment across chromosomes. Immunofluorescence staining for H3K9me3 in male mitotic chromosomes. Scale bar is 50μm. Credit: Nguyen AH et al., 2021, PLOS Genetics

Males may have shorter lifespans than females due to repetitive sections of the Y chromosome that create toxic effects as males get older. These new findings appear in a study by Doris Bachtrog of the University of California, Berkeley published April 22 in PLOS Genetics.

In humans and other species with XY sex chromosomes, females often live longer than . One possible explanation for this disparity may be repetitive sequences within the genome. While both males and females carry these repeat sequences, scientists have suspected that the large number of repeats on the Y chromosome may create a "toxic y effect" that shortens males' lives. To test this idea, Bachtrog studied male fruit flies from the species Drosophila miranda, which have about twice as much repetitive DNA as and a shorter lifespan. They showed that when the DNA is in its tightly packed form inside the cells of young male flies, the repeat sections are turned off. But as the flies age, the DNA assumes a looser form that can activate the repeat sections, resulting in .

The new study demonstrates that Y chromosomes that are rich in repeats are a genomic liability for males. The findings also support a more general link between repeat DNA and aging, which currently, is poorly understood. Previous studies in have shown that when repeat sections become active, they impair memory, shorten the lifespan and cause DNA damage. This damage likely contributes to aging's physiological effects, but more research will be needed to uncover the mechanisms underlying repeat DNA's .

More information: Nguyen AH, Bachtrog D (2021) Toxic Y chromosome: Increased repeat expression and age-associated heterochromatin loss in male Drosophila with a young Y chromosome. PLoS Genet 17(4): e1009438.

Journal information: PLoS Genetics

Citation: Toxic masculinity: Y chromosome contributes to a shorter lifespan in male flies (2021, April 22) retrieved 10 December 2023 from
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