Quorum sensing molecules: How the body cells spy out bacteria
Bacterial infection does not automatically lead to illness; many germs only become dangerous when they occur in large numbers. Researchers at the Max Planck Institute for Infection Biology in Berlin have discovered that the body has a receptor, which doesn't recognize bacteria themselves, but spies out their communication. The body uses this to register when so many bacteria are present that they secrete illness-inducing substances known as virulence factors.
In the case of opportunistic pathogens in the environment, this critical threshold for an infection is particularly high: only when they occur in very high numbers and/or form illness-inducing substances can they overwhelm a person.
Pseudomonas aeruginosa is one such germ. Everyone regularly comes into contact with it, as it is found predominantly in water pipes, wash basins and other similar places. However, large quantities of pseudomonads can cause serious illness. They do this by forming disease-inducing substances which enable them to gain a foothold in the host and cause damage. This germ can easily cause pneumonia, wound infections or bacteremia and blood poisoning, particularly in hospital patients. These diseases are extraordinarily difficult to treat, as the bacteria are highly resistant to antibiotics.
How do germs decide when the time is right for an attack? They communicate with one another via small molecules known as "quorum sensing molecules." Only when they have reached sufficient density do pseudomonads produce illness-inducing substances and mucous molecules, which defend them against antibiotics and the body's own immune system. This makes sense for the germs, because as long as mucus and virulence factors are not needed, their production only means unnecessary energy consumption. On the other hand, the energy expenditure is worthwhile during an actual attack, because only then can they successfully infect the host and use it as a "breeding ground."
Spotting communication among bacteria
Stefan Kaufmann and his team of researchers at the Max Planck Institute for Infection Biology have discovered that cells are able to spot communication amongst bacteria with the help of a receptor known as the aryl hydrocarbon receptor. This receptor detects the quorum sensing molecules, enabling body cells to detect when the bacteria are preparing for an attack. "Thanks to this spying, the body can activate the immune system in times of need to fend off an attack from these germs," explains the study's lead author, Pedro Moura-Alves, currently a group leader at the Ludwig Institute for Cancer Research, Oxford University.
In fact, the receptor eavesdrops on the bacteria before they have even reached their quorum; detecting the early stages of quorum sensing molecules inhibits the aryl hydrocarbon receptor, blocking a premature mobilization of the immune defenses. "This is effective for the host, as it saves energy to leave a small number of bacteria alone, provided they aren't causing any damage. Only when they've reached a critical mass is the energy required for defense mustered," says Stefan Kaufmann. This also helps prevent collateral damage caused by the immune system's response.
So the body not only recognizes whether germs are present or not; these recent results show that it also registers the way their numbers are growing, in order to react to differing stages of an infection.