A substance found in brown coal can help combat viruses

The substance found in brown coal can help combat viruses
Antiviral activity of ten humic substance (HS) samples was assessed against tick-borne encephalitis virus reproduction. To reveal possible active components of HS samples FTICR MS data were searched in ChEMBL database. Several structures possessing similar antiviral activity profile and matching isotopic exchange results were identified. Credit: Orlov A.A. (Skoltech)

Scientists from Russia have demonstrated a novel approach leveraging high-resolution mass spectrometry and chemoinformatics to identify biologically active molecular components of humic substances extracted from coal, and discovered substances with antiviral activity against the tick-borne encephalitis virus. The results of their study were published in the Scientific Reports journal.

Natural multicomponent mixtures, such as humic substances found in soil, peat and coal are a very important source of biologically . Understanding their composition and extracting can be a great help in creating new drugs. However, finding a specific compound in these environments is a highly challenging task that requires advanced methods capable of differentiating and separating one substance from another.

A joint study conducted by scientists from the Skolkovo Institute of Science and Technology (Skoltech) and institutional collaborators revealed that humic substances inhibit the reproduction of a dangerous human pathogen, tick-borne encephalitis virus. The authors relied on to study the composition of humic samples and chemoinformatics to analyze their findings. They compared the results against extensive databases of chemical and identified the compounds' structural features which may be responsible for their virucidal activity. The data analysis results clearly attest to the importance of natural central fragments of flavonoids and polyphenols, two classes of natural compounds with wide-ranging biological activity.

"We made an attempt at understanding the structural reasons behind the antiviral activity of the molecular components of humic substances. Aware that standard methods of complex mixture separation do not work for humic substances, we looked at some known structures matching the molecular compositions determinable by and noticed that some structures correspond to compounds often extracted from natural sources, for example, flavonoids. We undertook further mass spectrometry experiments, which suggest that there can indeed be a match between the types of structures we found in the databases and the molecular components of humic systems," says one of the authors of the study and Research Scientist at Skoltech, Alexander Zherebker, Ph.D.

The results of the study can serve as a stepping stone towards detailed research into the molecular mechanisms of biological activity exhibited by humic and other natural inseparable multicomponent mixtures and assessment of their pharmaceutical potential.


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More information: Alexey A. Orlov et al. Examination of molecular space and feasible structures of bioactive components of humic substances by FTICR MS data mining in ChEMBL database, Scientific Reports (2019). DOI: 10.1038/s41598-019-48000-y
Journal information: Scientific Reports

Citation: A substance found in brown coal can help combat viruses (2019, August 19) retrieved 19 September 2019 from https://phys.org/news/2019-08-substance-brown-coal-combat-viruses.html
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