New approach yields high-purity radium for medical applications

August 6, 2018, US Department of Energy
The radioisotope recovery flow sheet highlights how each step in the process removes specific elements from the solution while others pass to the next step, resulting in a pure final product. Los Alamos National Laboratory

Producing radium isotopes to treat cancer could get easier. Researchers developed a method to recover medical radium isotopes. The process begins with the dissolved proton-irradiated thorium target solution. The process then takes the solution through a series of columns. In each column, different isotopes bind to the different substrates the column contains. With the anticipated scale-up to large thorium targets, dozens of patient treatment doses would be available for recovery from a single production process. Los Alamos National Laboratory's Isotope Team devised the method with collaborators from Brookhaven National Laboratory and Oak Ridge National Laboratory.

The improvements result in high product yield and high purity for the isolated radium. The is modular. This allows integration into an automatable multi-nuclide recovery flow sheet. Radium is now isolated from the same experiment as therapy isotopes actinium-225, protactinium-230, -227, and uranium-230. The results appear in the Nature publisher's open-access journal Scientific Reports. The study was selected as one of the top 100 read papers. It was chosen from more than 5000 chemistry papers published in 2017.

Radium is a bone-seeking radioelement, due to its chemical similarity to calcium, the main component of hydroxyapatite, the bone mineral. Radium is thus "mistaken" for calcium in the body, which lets it accumulate in rapidly forming cells in bone metastases. Once incorporated into the cancer cells, the emitted alpha radiation promotes cancer cell death. Radium-223 is the first alpha-emitting isotope that obtained Food and Drug Administration approval for the treatment of cancer. Other radium isotopes of interest for preclinical research include radium-224 and radium-225. Researchers developed a novel methodology for the automated recovery of these radium isotopes from proton-irradiated thorium. Hundreds of millicuries of radium—corresponding to dozens of therapeutic patient doses—can be recovered in high yield and purity alongside other therapy isotopes during the same recovery process. The radium product obtained by this method is composed of radium-223, radium-224, and radium-225 and is suitable for chemistry applications (such as development of specialized ligands that hold radium with high selectivity inside a treatment compound) and possible treatment regimes. Because radium-225 decays into actinium-225, scientists can also use the radium isotope as a "generator" of pure actinium-225 for clinical applications as the other radium impurities do not decay to actinium .

Explore further: Radioactive isotopes reveal age of oil and gas wastewater spills

More information: Tara Mastren et al. Simultaneous Separation of Actinium and Radium Isotopes from a Proton Irradiated Thorium Matrix, Scientific Reports (2017). DOI: 10.1038/s41598-017-08506-9

Valery Radchenko et al. Radiometric evaluation of diglycolamide resins for the chromatographic separation of actinium from fission product lanthanides, Talanta (2017). DOI: 10.1016/j.talanta.2017.07.057

Related Stories

First Phase III trial of an alpha-pharmaceutical

September 23, 2011

Until recently, options for patients with bone metastases from advanced prostate cancer have been very limited. But now the first Phase III study of an alpha-pharmaceutical in these patients has shown that it can prolong ...

Simpler Radium Test Cuts Analysis Time

August 29, 2007

A simpler technique for testing public drinking water samples for the presence of the radioactive element radium can dramatically reduce the amount of time required to conduct the sampling required by federal regulations. ...

Recommended for you

Gravitational wave detectors to search for dark matter

August 16, 2018

Gravitational wave detectors might be able to detect much more than gravitational waves. According to a new study, they could also potentially detect dark matter, if dark matter is composed of a particular kind of particle ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.