Researchers find connection between viruses and inflammatory bowel disease

July 23, 2018, CU Anschutz Medical Campus
The Mycobacterium smegmatis phage MicroWolf. Credit: H. Hendricks, NC State Phage Hunters, E. Miller, NC State University.

A study led by a researcher at the University of Colorado Anschutz Medical Campus reveals a key connection between viruses and inflammatory bowel diseases like ulcerative colitis and Crohn's disease.

Breck Duerkop, Ph.D., assistant professor of immunology and microbiology at the University of Colorado School of Medicine, and a team of scientists focused on viruses inhabiting bacteria in the intestine known as bacteriophages or simply phages.

"Phage numbers are elevated at the intestinal mucosal surface and increase in abundance during (IBD), suggesting that phages play an unidentified role in IBD," said Duerkop, lead author of the study published Monday in the journal Nature Microbiology.

IBD poses significant health burdens worldwide and has inspired intense investigation into the environmental factors causing of the intestine. Microbial communities are critical in maintaining intestinal health but changes in the composition of these organisms may cause an inflammatory response by the body.

According to Duerkop, most studies looking at how these might spark inflammation have focused chiefly on bacteria rather than the viruses residing inside them.

When inflammation occurs, Duerkop found that phage communities change randomly leading to a genetic signature indicative of the inflammatory environment.

"We hypothesize that inflammation or other host defenses alter phage abundances during colitis," the study said. "Such stresses could produce ecological disturbances in the intestinal environment, driving alterations within the viral community."

Those disturbances could be the result of the viruses killing off in the intestine and allowing for `bad actor' bacteria to cause inflammation and bowel disease.

The experiments were done with mice.

"What we see in mice is consistent with what we see in humans with IBD," Duerkop said.

While the mechanics of how these phages operate will require further study, Duerkop said this discovery could lead to new kinds of treatment for these often debilitating diseases.

Clinicians could target certain bacteria with viruses to eliminate bacteria that lead to . Bacteria could be manipulated to circumvent the development of disease.

"We could promote the growth of good —a kind of phage therapy," Duerkop said. "We could perhaps use phages as markers to identify someone predisposed to developing these diseases. While there is clearly more research to do, the potential is very exciting."

Explore further: Researchers assassinate disease-causing bacteria with virus cocktail

More information: Breck A. Duerkop et al. Murine colitis reveals a disease-associated bacteriophage community, Nature Microbiology (2018). DOI: 10.1038/s41564-018-0210-y

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Anonym155970
1 / 5 (1) Jul 23, 2018
Change your diet, eat clean! Junk food, sugar and gmo's cause inflamation which than disrupts your whole system! Eat clean and inflamation will go away!
leetennant
5 / 5 (3) Jul 23, 2018
Change your diet, eat clean! Junk food, sugar and gmo's cause inflamation which than disrupts your whole system! Eat clean and inflamation will go away!


Not only is this nonsense, but it's nonsense that contradicts the findings in the article!

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