A lipid's role in cell division

A lipid’s role in cell division
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Proper cell division is a basic process critical to cell survival. A ring composed of actin filaments and myosin motor proteins pinches the cell apart, producing two daughter cells with equal amounts of cellular components.

Reporting in the Journal of Cell Biology, Kathleen Gould, Ph.D., and colleagues characterized how this powerful remains anchored to the allowing symmetric division.

Decreased amounts of the lipid family of phosphoinositides (PIPs) in the plasma membrane have been shown to cause cytokinesis defects. Despite this, how lipid levels could affect contractile ring function was unknown.

PIP levels are regulated by a known set of proteins including Efr3 in Schizosaccharomyces pombe. When efr3 was knocked out in S. pombe, PIP levels were reduced in the plasma membrane. Interestingly, the cytokinetic ring slid away from the cell center, leading to asymmetrical division.

The work suggests that contractile ring anchoring may be dependent on a plasma membrane localized complex regulating PIP levels.

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Building the ring to divide them all: Septin proteins bundle actin filaments into a ring

More information: Chloe E. Snider et al. Phosphoinositide-mediated ring anchoring resists perpendicular forces to promote medial cytokinesis, The Journal of Cell Biology (2017). DOI: 10.1083/jcb.201705070
Journal information: Journal of Cell Biology

Citation: A lipid's role in cell division (2017, November 13) retrieved 21 January 2022 from https://phys.org/news/2017-11-lipid-role-cell-division.html
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