Nipping flu pandemics in the bud

Nipping flu pandemics in the bud
Scientists are developing a disposable, easy-to-use flu detector that yields visible results (inset) in about 35 minutes. Credit: American Chemical Society

The threat of a major flu pandemic is a perennial concern. Now scientists have developed a fast and easy-to-use point-of-care diagnostic test that could one day help doctors and hospitals head off the rapid spread of the flu. They report their new device in ACS' journal Analytical Chemistry.

The gold standard of flu diagnostics involves expensive techniques, laboratory facilities, trained personnel and, most importantly, time. However, patients and doctors often don't have time on their side because some strains, such as H5N1, can cause severe illness and even death. And even common strains can be deadly in the elderly and small children. Existing can help with diagnoses, but these tests require multiple processing steps that still need to be performed with lab equipment in specialized facilities. So Paul Yager and colleagues set out to create a simpler, low-cost that can be used during an office or hospital visit without expensive instruments.

The researchers incorporated multiple steps of influenza detection—viral lysis, target protein capture, labeling, rinsing and an enzyme-driven color change—into one device. A user has to swab the inside of a patient's nose, then insert the swab into the device and twirl it for 10 seconds to release the virus. The device takes care of the rest. After about 35 minutes, it produces a visual readout that can be seen with the naked eye or captured with a smartphone camera. The researchers trained staff at a children's hospital to use the device, and they tested it on 25 patients during a . The device detected influenza A, one of the primary causes of moderate to severe flu epidemics, with 70 percent accuracy. The materials and reagents for one of these single-use devices cost less than $6.

More information: Shichu Huang et al. Disposable Autonomous Device for Swab-to-Result Diagnosis of Influenza, Analytical Chemistry (2017). DOI: 10.1021/acs.analchem.6b04801

Journal information: Analytical Chemistry

Citation: Nipping flu pandemics in the bud (2017, May 10) retrieved 31 January 2023 from
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