Strep spreads by harnessing immune defenses of those infected

January 11, 2017
Streptococcus pneumoniae in spinal fluid. Credit: CDC

The bacteria that cause most cases of pneumonia worldwide secrete a toxin that helps them jump from one body to the next - with help from the hosts' immune defenses. This is the finding of a study led by researchers from NYU Langone Medical Center and published online January 11 in Cell Host & Microbe.

The study explains survival "strategies" used by the bacteria Streptococcus pneumoniae, or pneumococcus, which causes millions of infections each year. Most often infecting the nasal cavity, sinuses and lungs, these infections can be deadly in patients with weak immune systems, especially young children and the elderly.

In the current study, conducted in mice, researchers determined that S. pneumoniae has evolved to give off a called pneumolysin, which causes a strong inflammatory immune reaction in airways. This in turn increases nasal secretions that enable cells lining mucous membranes to expel S.pneumoniae from the body.

Researchers argue that these bacteria have evolved to take advantage of being expelled, riding the secretions out of the body and on to their next . Researchers found that S. pneumoniae could not spread from one mouse pup to the next when the bacteria were genetically engineered to be unable to make the toxin.

"Factors that allow for the host-to-host transmission of disease-causing bacteria have not been thoroughly investigated by the field as a means of prevention," says Jeffrey Weiser, MD, chair of the Department of Microbiology at NYU Langone. "Our findings provide evidence of the tool used by these bacteria to spread, which promises to guide the design of new kinds of countermeasures."

Struggle in the Airways

Bacteria trying to survive on the surfaces of human airways must overcome two challenges not encountered by organisms that infect the gut. Firstly, healthy hosts do not regularly expel contents of their airways the way they do from their guts, which frees microbes to travel to their next host. Secondly, airways do not offer the same regular food supply to bacteria as the gut.

By emitting the pneumolysin toxin, S. pneumoniae "gets creative" in both finding nutrients and exiting its current host, say the study authors. The toxin evokes a strong response from the body, they say, because it is destructive, drilling holes (pores) into cells to get at the nutrients inside them. Thus, the toxin gets the bacteria food to hold them over while outside the body, and then, by triggering secretions, ensures that they exit a body that is assaulting them with inflammatory, immune responses. This helps them to quickly find a new and more hospitable host.

Framing the current results is past work that explains how S. pneumoniae spreads more effectively when a person also has the flu. The increased secretions that accompany influenza viral infection, when modeled in mice, were found to help pneumococcus overcome the population constraints that come with remaining in one host.

The current study authors modified a mouse model of bacterial transmission recently developed by another lab to study for the first time pneumococcal transmission when the flu is absent.

The authors show that inflammation induced by pneumococcal colonization alone, particularly in response to pneumolysin, was capable of causing bacterial shedding needed for transmission between hosts.

The study results also answered a long-held question in the field about why bacteria that depend on their relationship with their host give off such a destructive toxin. Why not live on over time in relative "peace," allowing your host to feed you? The answer, say the researchers, is that the benefit to the organism of a higher rate of transmission compensates for the damaging effects of the toxin on the host.

"Our study results argue that toxins made by are central mediators of transmission between hosts, which makes them attractive as a potential ingredient in vaccines, to which they could be added specifically to block transmission," says Weiser. "There are precedents in using disarmed bacterial toxins, or toxoids, as vaccine ingredients, as with existing vaccines against diphtheria, tetanus and pertussis."

Explore further: Scientists discover bacterial cause behind fatal heart complications

Related Stories

Toxin targets discovered

November 24, 2014

Research that provides a new understanding of how bacterial toxins target human cells is set to have major implications for the development of novel drugs and treatment strategies.

Why pneumococci affect primarily humans

September 1, 2016

A special variant of a sugar molecule in the human nose might explain why pneumococcal infections are more common in humans than in other animals, researchers from Karolinska Institutet in Sweden report in a study published ...

Flu helps spread pneumonia

April 11, 2011

Bacteria that cause pneumonia and meningitis are only able to spread when individuals are infected with flu, says a scientist reporting at the Society for General Microbiology's Spring Conference in Harrogate. The work could ...

Recommended for you

Tasmanian tiger doomed long before humans came along

December 12, 2017

The Tasmanian tiger was doomed long before humans began hunting the enigmatic marsupial, scientists said Tuesday, with DNA sequencing showing it was in poor genetic health for thousands of years before its extinction.

Searching for the CRISPR Swiss-army knife

December 12, 2017

Scientists at the University of Copenhagen, led by the Spanish Professor Guillermo Montoya, are investigating the molecular features of different molecular scissors of the CRISPR-Cas system to shed light on the so-called ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.