Neanderthal inheritance helped humans adapt to life outside of Africa

Comparison of Modern Human and Neanderthal skulls from the Cleveland Museum of Natural History. Credit: DrMikeBaxter/Wikipedia

As the ancestors of modern humans made their way out of Africa to other parts of the world many thousands of years ago, they met up and in some cases had children with other forms of humans, including the Neanderthals and Denisovans. Scientists know this because traces of those meetings remain in the human genome. Now, researchers reporting in the Cell Press journal Current Biology on November 10 find more evidence that those encounters have benefited humans over the years.

All told, the new study identifies 126 different places in the where genes inherited from those remain at unusually high frequency in the genomes of modern humans around the world. We owe our long-lost hominid relatives for various traits, and especially those related to our immune systems and skin, the evidence shows.

"Our work shows that hybridization was not just some curious side note to human history, but had important consequences and contributed to our ancestors' ability to adapt to different environments as they dispersed throughout the world," says Joshua Akey of University of Washington School of Medicine in Seattle.

Akey says it's relatively straightforward today to identify sequences that were inherited from archaic ancestors. Studies show that non-African individuals inherited about 2% of their genomes from Neanderthals. People of Melanesian ancestry inherited another 2% to 4% of their genomes from Denisovan ancestors. But it hasn't been clear what influence those DNA sequences have had on our biology, traits, and evolutionary history.

In the new study, the researchers took advantage of recently constructed genome-scale maps of Neanderthal and Denisovan sequences identified in more than 1,500 geographically diverse people. Their sample included close to 500 individuals each from East Asia, Europe, and South Asia. They also analyzed the genomes of 27 individuals from Island Melanesia, an area including Indonesia, New Guinea, Fiji, and Vanuatu. The researchers were searching for archaic DNA sequences in those human genomes at frequencies much higher than would be expected if those genes weren't doing people any good.

While the vast majority of surviving Neanderthal and Denisovan sequences are found at relatively low frequencies (typically less than 5%), the new analyses turned up 126 places in our genomes where these archaic sequences exist at much higher frequencies, reaching up to about 65%. Seven of those regions were found in parts of the genome known to play a role in characteristics of our skin. Another 31 are involved in immunity.

"The ability to increase to such high population frequencies was most likely facilitated because these sequences were advantageous," Akey explains. "In addition, many of the high-frequency span genes involved in the immune system, which is a frequent target of adaptive evolution."

Generally speaking, the genes humans got from Neanderthals or Denisovans are important for our interactions with the environment. The evidence suggests that hybridization with archaic humans as our ancient ancestors made their way out of Africa "was an efficient way for to quickly adapt to the new environments they were encountering."

The researchers say they'd now like to learn more about how these genes influenced humans' ability to survive and what implications they might have for disease. They are also interested in expanding their analysis to include geographically diverse populations in other parts of the world, including Africa.

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More information: Current Biology, Gittelman et al.: "Archaic Hominin Admixture Facilitated Adaptation to Out-of-Africa Environments" , DOI: 10.1016/j3.cub.2016.10.041
Journal information: Current Biology

Provided by Cell Press
Citation: Neanderthal inheritance helped humans adapt to life outside of Africa (2016, November 10) retrieved 21 July 2019 from
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Nov 10, 2016
Really? People who moved into western world - from Africa to Europe or Americas - don't seem to have that much detriment living here. Neither last year, nor last 10 years, last 100 years, last 500 years, you name it.

Neither I see people of African origin acquiring deadly illnesses or conditions after a hiking trip into Rocky Mountains wilderness these days.

Obviously, the Neanderthal additional genes seem unlikely to be vital for survival of humans.

But, have to publish or perish? Having or not having Neanderthal's genes will not make you perish. Not publishing - will.

Nov 11, 2016
Life in the Americas was incredibly challenging for the first people here.

This article is also referring to a time before farming and civilizations, and people get sick all the time when they travel.

What are you mad about?

Nov 13, 2016
Really? People who moved into western world - from Africa to Europe or Americas - don't seem to have that much detriment living here. Neither last year, nor last 10 years, last 100 years, last 500 years, you name it
?? Things were lots different back during the pleistocene weren't they?

Tropical interlopers would have much to gain for their offspring by mating with indigenes who are the result of many gens of adaptation.

Conversely, temperate- and subarctic-adapted people would have much to lose for their offspring by mating with tropical interlopers.

Today we call this resistance 'bigotry'.

The farther north a species resides the more seasonal it's reproduction becomes. It's too bad that cromags did not inherit neanderthal mating seasons. Although the tendency is there with June weddings and rites of spring festivals.

Overpopulation wouldn't be a problem if we weren't an invasive tropical species in a temperate environment.

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