Nobel Prize winner Roger Tsien dies; helped track cells

August 31, 2016
This Dec. 7, 2008 file photo shows Nobel Prize in Chemistry laureate Roger Y. Tsien speaks during the press conference at the Royal Swedish Academy of Sciences in Stockholm, Sweden. Tsien, who won a Nobel Prize for helping create colorful markers that can help tag cancer tumors or track the development of Alzheimer's disease, has died. Tsien died on Aug. 24, 2016. in Eugene, Ore., according to a statement Wednesday, Aug 31, from the university. (Fredrik Persson/Scanpix, Fredrik Persson via AP, File)

Roger Tsien, a University of California, San Diego professor who shared the 2008 Nobel Prize in chemistry for helping develop fluorescent markers that could tag cancer cells or track the advance of Alzheimer's disease in the brain, has died. He was 64.

Tsien died on Aug. 24 in Eugene, Oregon, according to a statement Wednesday from the university.

UC San Diego Chancellor Pradeep Khosla said that Tsien apparently died while on a bike trail, the San Diego Union-Tribune reported (bit.ly/2bSZn8Z ), but the cause of death had not been determined.

"Roger was an extraordinary man: kind, generous, gracious, and always the consummate scientist pushing the limits of his work to expand the possibilities of science," Khosla said. "He was a rare talent we cannot replace."

Tsien was a professor of pharmacology, chemistry and biochemistry at UC San Diego's School of Medicine for 27 years.

In 2008, he shared the Nobel with Osamu Shimomura and Martin Chalfie for helping turn green fluorescent protein from a jellyfish into a research tool that could literally illuminate everything from brain cells to bacteria.

Tsien helped create markers that, under ultraviolet light, glow in a wide variety of colors. Researchers use the markers to track cellular processes.

"Our work is often described as building and training molecular spies," Tsien once said, according to the university. "Molecules that will enter a cell or organism and report back to us what the conditions are, what's going on with the biochemistry, while the cell is still alive."

This Oct. 8, 2008 file photo shows Roger Tsien, PHD, talks about his research at a news conference at the University of California-San Diego. Tsien, who won a Nobel Prize for helping create colorful markers that can help tag cancer tumors or track the development of Alzheimer's disease, has died. Tsien was 64. The university says he died Aug. 24, 2016, in Eugene, Ore. (AP Photo/Lenny Ignelzi, File)

A version that surgeons can use to differentiate cancerous tissue from healthy tissue is currently in development.

"I've always been attracted to colors," Tsien told the Union-Tribune in 2008. "Color helps make the work more interesting and endurable. It helps when things aren't going well. If I had been born colorblind, I probably never would have gone into this."

Born in New York City, Tsien began sketching chemistry experiments when he was 8 years old, according to the university, and earned his first Boy Scout merit badge in chemistry. He took degrees from Harvard and Cambridge.

"He was ahead of us all," Tsien's wife, Wendy, said in the university statement. "He was ever the adventurer, the pathfinder, the free and soaring spirit. Courage, determination, creativity and resourcefulness were hallmarks of his character. He accomplished much. He will not be forgotten."

Explore further: Expression of infrared fluorescence engineered in mammals

Related Stories

Expression of infrared fluorescence engineered in mammals

May 7, 2009

(PhysOrg.com) -- Researchers at the University of California, San Diego - led by 2008 Nobel-Prize winner Roger Tsien, PhD - have shown that bacterial proteins called phytochromes can be engineered into infrared-fluorescent ...

New fluorescent dyes highlight neuronal activity

January 25, 2012

Researchers at the University of California, San Diego School of Medicine have created a new generation of fast-acting fluorescent dyes that optically highlight electrical activity in neuronal membranes. The work is published ...

Fluorescent probes light up cancerous tumors

February 16, 2010

Building on his Nobel Prize-winning work creating fluorescent proteins that light up the inner workings of cells, a team of researchers led by Howard Hughes Medical Institute investigator Roger Tsien, PhD, professor of pharmacology, ...

Recommended for you

The powerful meteor that no one saw (except satellites)

March 19, 2019

At precisely 11:48 am on December 18, 2018, a large space rock heading straight for Earth at a speed of 19 miles per second exploded into a vast ball of fire as it entered the atmosphere, 15.9 miles above the Bering Sea.

OSIRIS-REx reveals asteroid Bennu has big surprises

March 19, 2019

A NASA spacecraft that will return a sample of a near-Earth asteroid named Bennu to Earth in 2023 made the first-ever close-up observations of particle plumes erupting from an asteroid's surface. Bennu also revealed itself ...

Nanoscale Lamb wave-driven motors in nonliquid environments

March 19, 2019

Light driven movement is challenging in nonliquid environments as micro-sized objects can experience strong dry adhesion to contact surfaces and resist movement. In a recent study, Jinsheng Lu and co-workers at the College ...

Revealing the rules behind virus scaffold construction

March 19, 2019

A team of researchers including Northwestern Engineering faculty has expanded the understanding of how virus shells self-assemble, an important step toward developing techniques that use viruses as vehicles to deliver targeted ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.