Nobel Prize winner Roger Tsien dies; helped track cells

August 31, 2016
This Dec. 7, 2008 file photo shows Nobel Prize in Chemistry laureate Roger Y. Tsien speaks during the press conference at the Royal Swedish Academy of Sciences in Stockholm, Sweden. Tsien, who won a Nobel Prize for helping create colorful markers that can help tag cancer tumors or track the development of Alzheimer's disease, has died. Tsien died on Aug. 24, 2016. in Eugene, Ore., according to a statement Wednesday, Aug 31, from the university. (Fredrik Persson/Scanpix, Fredrik Persson via AP, File)

Roger Tsien, a University of California, San Diego professor who shared the 2008 Nobel Prize in chemistry for helping develop fluorescent markers that could tag cancer cells or track the advance of Alzheimer's disease in the brain, has died. He was 64.

Tsien died on Aug. 24 in Eugene, Oregon, according to a statement Wednesday from the university.

UC San Diego Chancellor Pradeep Khosla said that Tsien apparently died while on a bike trail, the San Diego Union-Tribune reported (bit.ly/2bSZn8Z ), but the cause of death had not been determined.

"Roger was an extraordinary man: kind, generous, gracious, and always the consummate scientist pushing the limits of his work to expand the possibilities of science," Khosla said. "He was a rare talent we cannot replace."

Tsien was a professor of pharmacology, chemistry and biochemistry at UC San Diego's School of Medicine for 27 years.

In 2008, he shared the Nobel with Osamu Shimomura and Martin Chalfie for helping turn green fluorescent protein from a jellyfish into a research tool that could literally illuminate everything from brain cells to bacteria.

Tsien helped create markers that, under ultraviolet light, glow in a wide variety of colors. Researchers use the markers to track cellular processes.

"Our work is often described as building and training molecular spies," Tsien once said, according to the university. "Molecules that will enter a cell or organism and report back to us what the conditions are, what's going on with the biochemistry, while the cell is still alive."

This Oct. 8, 2008 file photo shows Roger Tsien, PHD, talks about his research at a news conference at the University of California-San Diego. Tsien, who won a Nobel Prize for helping create colorful markers that can help tag cancer tumors or track the development of Alzheimer's disease, has died. Tsien was 64. The university says he died Aug. 24, 2016, in Eugene, Ore. (AP Photo/Lenny Ignelzi, File)

A version that surgeons can use to differentiate cancerous tissue from healthy tissue is currently in development.

"I've always been attracted to colors," Tsien told the Union-Tribune in 2008. "Color helps make the work more interesting and endurable. It helps when things aren't going well. If I had been born colorblind, I probably never would have gone into this."

Born in New York City, Tsien began sketching chemistry experiments when he was 8 years old, according to the university, and earned his first Boy Scout merit badge in chemistry. He took degrees from Harvard and Cambridge.

"He was ahead of us all," Tsien's wife, Wendy, said in the university statement. "He was ever the adventurer, the pathfinder, the free and soaring spirit. Courage, determination, creativity and resourcefulness were hallmarks of his character. He accomplished much. He will not be forgotten."

Explore further: Expression of infrared fluorescence engineered in mammals

Related Stories

Expression of infrared fluorescence engineered in mammals

May 7, 2009

(PhysOrg.com) -- Researchers at the University of California, San Diego - led by 2008 Nobel-Prize winner Roger Tsien, PhD - have shown that bacterial proteins called phytochromes can be engineered into infrared-fluorescent ...

New fluorescent dyes highlight neuronal activity

January 25, 2012

Researchers at the University of California, San Diego School of Medicine have created a new generation of fast-acting fluorescent dyes that optically highlight electrical activity in neuronal membranes. The work is published ...

Fluorescent probes light up cancerous tumors

February 16, 2010

Building on his Nobel Prize-winning work creating fluorescent proteins that light up the inner workings of cells, a team of researchers led by Howard Hughes Medical Institute investigator Roger Tsien, PhD, professor of pharmacology, ...

Recommended for you

Squid could provide an eco-friendly alternative to plastics

February 21, 2019

The remarkable properties of a recently-discovered squid protein could revolutionize materials in a way that would be unattainable with conventional plastic, finds a review published in Frontiers in Chemistry. Originating ...

Female golden snub-nosed monkeys share nursing of young

February 21, 2019

An international team of researchers including The University of Western Australia and China's Central South University of Forestry and Technology has discovered that female golden snub-nosed monkeys in China are happy to ...

When does one of the central ideas in economics work?

February 20, 2019

The concept of equilibrium is one of the most central ideas in economics. It is one of the core assumptions in the vast majority of economic models, including models used by policymakers on issues ranging from monetary policy ...

In colliding galaxies, a pipsqueak shines bright

February 20, 2019

In the nearby Whirlpool galaxy and its companion galaxy, M51b, two supermassive black holes heat up and devour surrounding material. These two monsters should be the most luminous X-ray sources in sight, but a new study using ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.