Enhancing lab-on-a-chip peristalsis with electro-osmosis

May 10, 2016, American Institute of Physics
A diagram of electric fields employed for modification of electrolytic flow through peristalsis. Credit: A. Bandopadhyay&S. Chakraborty /Univ. Rennes&Indian Institute of Technology Kharagpur

If you've ever eaten food while upside down - and who hasn't indulged this chimpanzee daydream? - you can thank the successive wave-like motions of peristalsis for keeping the chewed bolus down and ferrying it into your stomach. In mechanical microdevices, this method of transport moves fluids without a separate pump- saving precious space in lab-on-a-chip and futuristic organ-on-a-chip devices - but this transport method is difficult to finely control.

To remedy this, researchers at the Indian Institute of Technology's Advanced Technology Development Center in Kharagpur, West Bengal have conducted lubrication theory-based analyses to explore the hydrodynamic effects of improving flow rate in pre-existing peristaltic hardware relying on an external . Their research, which assesses the combined effects of electric fields and peristalsis on the channel flow rate, appears this week in Physics of Fluids.

"Through our theoretical analysis, we've shown that by keeping the same peristalsis hardware, we may obtain an enhanced on-the-fly controllability of the by augmenting the device with electric fields," said Suman Charkraborty, a professor in the institute's Mechanical Engineering Department, and the Head of its School of Medical Science and Technology.

According to Chakraborty, an electric field component can easily be implemented because existing microtubule fabrication often involves sputtering electrodes onto the ends of the tubes - when a field is switched on, these electrodes cause fluid flow by attracting charged fluid toward the compatible electrode.

This has the potential to aid researchers in studying targeted drug delivery, augmenting biophysical fluid transport in human bodies, and observing and controlling chemical reaction and mixing in surface-modulated fluid flow environments, Chakraborty said.

Future work for Chakraborty and his colleagues includes analyzing the motion of charged particles in the electroosmotically-modulated peristaltic environment - a tricky matter, due to the interactions between fluidic drag, via the electric field, and electrophoretic particle motion. The researchers are also working to develop nanoscale energy harvesting, microfluidics-based portable kits for rapid medical diagnostics, and microfluidic tools to deepen our understanding of the physiological dynamics of living systems.

Explore further: New technique controls fluids at the nanoscale

More information: "Electroosmosis-modulated peristaltic transport in microfluidic channels," by Aditya Bandopadhyay, Dharmendra Tripathi, and Suman Chakraborty, Physics of Fluids , March 15, 2016 , DOI: 10.1063/1.4947115

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Hyperfuzzy
1 / 5 (1) May 12, 2016
Can the same be created with a modulated field, with feedback? Using the superimpose state as the source to define the object. Just need some cool e(r,t) tools. Simple let's simulate the possibility based upon known and controllable physics the motion defined within the superposition, it's only space and time? An infinite singularity or simply an infinite number of spatial singularity relative to another set! oop's tech not there yet. Why do you think you exist? We're all part of this wrinkle in space time, controllability and knowledge! Star Trek Scanner! The "Field" Luke! Put an electric eel into your genetics defined by this simple tool, and give yourself field control with a wave of your hand. Written into your genes. Become Gods!
Hyperfuzzy
1 / 5 (1) May 12, 2016
If there is only the +&- field centers, then this describes space. We can define every point from -infinity to +infinity, might need a hardware modification of memory addressing defined to search a particular scale, i.e. smart memory can define any point in this space based upon the location of every other. in the hw, ( each location holds e(self), e(Everyone else) and a simple point in 4D space, I define time as distance, i.e. lambda. Then you may throw away units, pick your scale, very small lambda or... creative visualization depth based upon same physics, i.e. memory depth, note each point is single point in time, it can be any, there is no, initiation. juz say'n

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