A microbial metabolite of linoleic acid ameliorates intestinal inflammation

February 18, 2015, Hiroshima University
HYA, a microbial metabolite of linoleic acid, ameliorates intestinal barrier damage. Credit: Tanebe et al, The Journal of Biological Chemistry, DOI: 10.1074/jbc.M114.610733, FIG.3A

Inflammatory bowel diseases (IBDs), including Crohn disease and ulcerative colitis, are hard to completely cure. Globally, IBDs affect more than 4 million people, today. However, Professor Soichi Tanabe (Graduate School of Biosphere Science, Hiroshima University) and his collaborators have demonstrated that 10-hydroxy-cis-12-octadecenoic acid (HYA), a gut microbial metabolite of linoleic acid, has a suppressive effect on intestinal inflammation. HYA is expected to be practically applied as a functional food.

The results of this group's research were published in The Journal of Biological Chemistry as "A gut microbial metabolite of linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, ameliorates intestinal epithelial barrier impairment partially via GPR40-MEK-ERK pathway" DOI: 10.1074/jbc.M114.610733.

IBD patients characteristically demonstrate increased expression of receptor-2 and an upregulated inflammatory NF-κB pathway. Professor Tanabe and his colleagues demonstrated that HYA binds to a G protein-coupled receptor (GPR40) and ameliorates intestinal epithelial barrier impairment in an intestinal epithelial cell line, Caco-2 cells; oral administration of HYA also alleviates colitis in mice.

The physiological activity of gut microbial metabolites has recently attracted considerable attention. HYA may be useful in the treatment of tight junction-related disorders, such as IBD.

Explore further: People may inherit 'gut' bacteria that cause Crohn's disease and ulcerative colitis

Related Stories

'Normal' bacteria vital for keeping intestinal lining intact

August 1, 2014

Scientists at Albert Einstein College of Medicine of Yeshiva University have found that bacteria that aid in digestion help keep the intestinal lining intact. The findings, reported online in the journal Immunity, could yield ...

New approach to preventing fibrosing strictures in IBD

January 15, 2015

A natural protein made by immune cells may limit fibrosis and scarring in colitis, according to research published in the inaugural issue of Cellular and Molecular Gastroenterology and Hepatology, the new basic science journal ...

Recommended for you

Materials chemists tap body heat to power 'smart garments'

January 22, 2019

Many wearable biosensors, data transmitters and similar tech advances for personalized health monitoring have now been "creatively miniaturized," says materials chemist Trisha Andrew at the University of Massachusetts Amherst, ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.