An activity-based probe library for identifying protein function

Proteins are vital to living systems. They build and repair tissues, act as enzymes to speed chemical reactions, regulate hormones and transport nutrients—all of which are important for developing next-generation bioproducts ...

Predictive tools can confuse rare mutations with dangerous ones

When a patient's DNA is read, it is compared with a reference version of the human genome. This allows geneticists and rare disease experts to look at a list of places where the patient's DNA differs. Most variations will ...

'Green thumb' molecule helps leaf stalks grow in crowded conditions

Potassium (K) is one of the three essential nutrients for plants. It plays a critical role in a wide range of processes, including cell growth, photosynthesis and regulation of water balance. Plants take up K from the soil ...

A molecular brake that keeps muscle architecture in check

Every movement we make, from blinking to sprinting, depends on the ability of muscle fibers to contract in a rapid and coordinated way. Achieving this precision requires an intricate internal membrane network known as the ...

How stressed cells put the brakes on protein 'shipping'

Cells synthesize proteins in the endoplasmic reticulum (ER), and these proteins are transported to the Golgi apparatus for distribution to their ultimate destinations inside and outside the cell. The structures that transport ...

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